MonoMethyl auristatin E - Moligand™, ≥97% , CAS No.474645-27-7

Name: MonoMethyl auristatin E - Moligand™, ≥97% , CAS No.474645-27-7
Brand: Aladdin Scientific
SKU: M303780
Availability: InStock

CAS: 474645-27-7 Cat. No.: M303780 Molecular Weight: 717.98 EC Number: 811-424-8

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MonoMethyl auristatin E - Moligand™, ≥97% CAS No(474645-27-7) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥97%

Synonyms

L-Valinamide, N-methyl-L-valyl-N-((1S,2R)-4-((2S)-2-((1R,2R)-3-(((1R,2S)-2-hydroxy-1- methyl-2-phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)-1-pyrrolidinyl)-2- methoxy-1-((1S)-1-methylpropyl)-4-oxobutyl)-N-methyl- | Monomethyl auristatin E (MMAE) | D

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Size

Status

Price

Qty

5mg

M303780-5mg

$9.90

10mg

M303780-10mg

$10.90

25mg

M303780-25mg

$20.90

$31.90
Save $11.00 (34.48%)

50mg

M303780-50mg

$35.90

$53.90
Save $18.00 (33.40%)

100mg

M303780-100mg

$54.90

$82.90
Save $28.00 (33.78%)

250mg

M303780-250mg

$84.90

$127.90
Save $43.00 (33.62%)

M303780-1g

8-12 wks(?)

$239.90

$359.90
Save $120.00 (33.34%)

M303780-5g

8-12 wks(?)

$870.90

$1,306.90
Save $436.00 (33.36%)

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Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Solution Calculators Reviews

🧪

Why this grade

Moligand™, ≥97% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C,Argon charged,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

L-Valinamide, N-methyl-L-valyl-N-((1S, 2R)-4-((2S)-2-((1R, 2R)-3-(((1R, 2S)-2-hydroxy-1- methyl-2-phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)-1-pyrrolidinyl)-2- methoxy-1-((1S)-1-methylpropyl)-4-oxobutyl)-N-methyl- | Monomethyl auristatin E (MMAE) | D

Specifications & Purity

Moligand™, ≥97%

Biochemical and Physiological Mechanisms

Monomethyl Auristatin E (MMAE) is a highly potent peptidyl antimitotic agent that blocks the polymerization of tubulin. Monomethyl Auristatin E is a component of a clinically approved antibodydirected conjugates Brentuximab vedotin, Glembatumumab vedotin,

Storage

Protected from light, Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥97%

Names and Identifiers

Pubchem Sid	504766531
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766531
Canonical Smiles	CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC
IUPAC Name	(2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide
InChIKey	DASWEROEPLKSEI-UIJRFTGLSA-N
INCHI	1S/C39H67N5O7/c1-13-25(6)34(43(10)39(49)33(24(4)5)42-38(48)32(40-9)23(2)3)30(50-11)22-31(45)44-21-17-20-29(44)36(51-12)26(7)37(47)41-27(8)35(46)28-18-15-14-16-19-28/h14-16,18-19,23-27,29-30,32-36,40,46H,13,17,20-22H2,1-12H3,(H,41,47)(H,42,48)/t25-,26+,27+,29-,30+,32-,33-,34-,35+,36+/m0/s1
Isomeric SMILES	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
Molecular Weight	717.98
Reaxy-Rn	33690997
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33690997&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Peptidomimetics
    - Subclass Hybrid peptides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Peptidomimetics
Subclass	Hybrid peptides
Intermediate Tree Nodes	Not available
Direct Parent	Hybrid peptides
Alternative Parents	Dipeptides Valine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Phenylpropanes N-acylpyrrolidines N-acyl amines Tertiary carboxylic acid amides Secondary alcohols Secondary carboxylic acid amides Dialkylamines Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Aromatic alcohols
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Hybrid peptide - Alpha-dipeptide - Valine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Phenylpropane - N-acylpyrrolidine - Monocyclic benzene moiety - Fatty amide - Fatty acyl - N-acyl-amine - Benzenoid - Tertiary carboxylic acid amide - Pyrrolidine - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Secondary alcohol - Secondary amine - Carboxylic acid derivative - Organoheterocyclic compound - Azacycle - Dialkyl ether - Ether - Secondary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Aromatic alcohol - Organic nitrogen compound - Carbonyl group - Organic oxide - Alcohol - Amine - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

BT-474 (2113 Activities)

Lot Number	Certificate Type	Date	Item
I2525691	Certificate of Analysis	Aug 14, 2025	M303780
I2525692	Certificate of Analysis	Aug 14, 2025	M303780
J2516849	Certificate of Analysis	Aug 14, 2025	M303780
J2214456	Certificate of Analysis	Jul 10, 2025	M303780
J2214488	Certificate of Analysis	Jul 10, 2025	M303780
J2214497	Certificate of Analysis	Jul 10, 2025	M303780
J2214517	Certificate of Analysis	Jul 10, 2025	M303780
A2211833	Certificate of Analysis	Nov 05, 2024	M303780
A2211850	Certificate of Analysis	Nov 05, 2024	M303780
A2211851	Certificate of Analysis	Nov 05, 2024	M303780

Solubility	Solvent:DMSO, Max Conc. mg/mL: 71.8, Max Conc. mM: 100
Sensitivity	Moisture & Light sensitive
Melt Point(°C)	>90°C (dec.)
Molecular Weight	718.000 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	20
Exact Mass	717.504 Da
Monoisotopic Mass	717.504 Da
Topological Polar Surface Area	150.000 Å²
Heavy Atom Count	51
Formal Charge	0
Complexity	1100.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

MonoMethyl auristatin E - Moligand™, ≥97% , CAS No.474645-27-7

Why this grade

Storage & shipping

Quality documents

Literature proof

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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