Nafamostat Mesylate - Moligand™, ≥98% , CAS No.82956-11-4

CAS: 82956-11-4 Cat. No.: N129262 Formula: C₁₉H₁₇N₅O₂·2CH₄O₃S Peso molecolare: 539.58 Numero EC: 692-168-2

GRADE & PURITY Moligand™, ≥98%

Synonyms

FUT-175 | 6-amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate | CCG-207877 | Nafamstat | 6-AMIDINO-2-NAPHTHYL P-GUANIDINOBENZOATE, DIMETHANESULPHONATE | nafamostat mesilate | NAFAMOSTAT MESILATE [WHO-DD] | 4-Guanidinobenzoic Acid 6-Amidino-2-nap

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Panoramica

Nafamostat mesilate is a synthetic serine protease inhibitor, used as an anticoagulant during hemodialysis.
A highly effective tryptase inhibitor.

Specifications

Sinonimi

FUT-175 | 6-amidino-2-naphthyl 4-guanidino-benzoate dimethanesulphonate | CCG-207877 | Nafamstat | 6-AMIDINO-2-NAPHTHYL P-GUANIDINOBENZOATE, DIMETHANESULPHONATE | nafamostat mesilate | NAFAMOSTAT MESILATE [WHO-DD] | 4-Guanidinobenzoic Acid 6-Amidino-2-nap

Specifiche e purezza

Moligand™, ≥98%

Meccanismi biochimici e fisiologici

Nafamostat mesylate is a highly effective tryptase (Ki=95.3 pM) inhibitor. The compound has the ability to promote synthesis of interferon-γ, tumor necrosis factor-α, IL-12, and IL-18. Additionally, Nafamostat mesylate can induce production of intercellul

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Protected from light

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥98%

Nomi e identificatori

Pubchem Sid

488195307

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488195307

Sorrisi canonici

CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

IUPAC Name

(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate;methanesulfonic acid

InChIKey

SRXKIZXIRHMPFW-UHFFFAOYSA-N

INCHI

1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)

Isomeri SMILES

CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

RTECS

DG2736000

Peso molecolare

539.58

Reaxy-Rn

24731990

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24731990&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives
        • Level5 Aminobenzoic acids and derivatives
          • Level6 Guanidinobenzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Aminobenzoic acids and derivatives
• Direct Parent: Guanidinobenzoic acids and derivatives
• Alternative Parents: Benzoic acid esters Naphthalenes Benzoyl derivatives Sulfonyls Alkanesulfonic acids Organosulfonic acids Carboxylic acid esters Guanidines Propargyl-type 1,3-dipolar organic compounds Carboxamidines Carboximidamides Monocarboxylic acids and derivatives Organooxygen compounds Organic salts Organic oxides Hydrocarbon derivatives Organopnictogen compounds
• Molecular Framework: Not available
• Substituents: Guanidinobenzoic acid or derivatives - Benzoate ester - Naphthalene - Benzoyl - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - Carboxylic acid ester - Guanidine - Organic 1,3-dipolar compound - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid amidine - Carboxylic acid derivative - Amidine - Monocarboxylic acid or derivatives - Organic salt - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homopolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as guanidinobenzoic acids and derivatives. These are aromatic compounds containing a guanidine group linked to the benzene ring of a benzoic acid (or a derivative thereof).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

Caco-2 (12174 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Soluble in DMSO (>10 mg/ml), water (25 mg/ml) Note: Phosphate-containing buffers may cause precipitation, and ethanol (<1 mg/mL) at 25 °C.
• Sensibilità: Moisture sensitive，Light sensitive
• Punto di fusione (°C): 260°C
• Peso molecolare: 539.600 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 5
• Exact Mass: 539.114 Da
• Monoisotopic Mass: 539.114 Da
• Topological Polar Surface Area: 266.000 Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 645.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 82956-11-4, the molecular formula is C19H17N5O2·2CH4O3S, and the molecular weight is 539.58 g/mol. InChIKey SRXKIZXIRHMPFW-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.