Nigericin - Moligand™, 10 mM in Ethanol , CAS No.28380-24-7

CAS: 28380-24-7 Cat. No.: N1495817 Molecular Weight: 724.96 Beilstein Registry Number: 3892398 EC Number: 686-881-8 PubChem CID: 34230

GRADE & PURITY Moligand™, 10 mM in Ethanol

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin induces pyroptosis through caspase 1 /GSDMD in TNBC.

Specifications

Specifications & Purity

Moligand™, 10 mM in Ethanol

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
• PubChem CID: 34230
• Molecular Weight: 724.96
• Beilstein: 3892398

References

1. Junyong Sun, Pinghua Ling, Feng Gao.  (2017)  A Mitochondria-Targeted Ratiometric Biosensor for pH Monitoring and Imaging in Living Cells with Congo-Red-Functionalized Dual-Emission Semiconducting Polymer Dots.  ANALYTICAL CHEMISTRY,      [PMID:29039196] [10.1021/acs.analchem.7b03154]

2. Tingwang Guo, Gang Chen, Lin Yang, Jia Deng, Yun Pan.  (2024)  Piezo1 inhibitor isoquercitrin rescues neural impairment mediated by NLRP3 after intracerebral hemorrhage.  EXPERIMENTAL NEUROLOGY,      [PMID:38857751] [10.1016/j.expneurol.2024.114852]