NMDA (N-Methyl-D-aspartic acid)(NMDA) - Moligand™, 10mM in DMSO , Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D, CAS No.6384-92-5, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

CAS: 6384-92-5 Cat. No.: N407747 Molecular Weight: 147.13 Beilstein Registry Number: 1724431

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

D-Aspartic acid, N-methyl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

NMDA（N-Methyl-D-aspartic acid）is a specific agonist forNMDAreceptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.
In vitro

NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca²⁺ and Na⁺ into the cell and K⁺ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca²⁺ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy).

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Synonyms

D-Aspartic acid, N-methyl-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

Names and Identifiers

• Isomeric SMILES: CN[C@H](CC(=O)O)C(=O)O
• RTECS: CI9457000
• Molecular Weight: 147.13
• Beilstein: 1724431
• Reaxy-Rn: 1724430
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1724430&ln=

Associated Targets(Human)

HPN Tchem Serine protease hepsin (0 Activities)

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.81 mM); Ethanol: 15 mg/mL warmed with 50ºC Water: bath (51.67 mM); Water: Insoluble
• Specific Rotation[α]: -15° (C=2,H2O)
• Melt Point(°C): 178 °C

References

1. Ting Ma, Xiaoxuan Wang, Ting Yu, Juan Liu, Zheqiong Yang, Jinlei Xi.  (2023)  Oxytetracycline changes the behavior of zebrafish larvae by inhibiting NMDA receptors.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:37567108] [10.1016/j.ecoenv.2023.115344]

2. Meixi He, Yi Wang, Xiaozhe Zhang, Lihua Zhang.  (2023)  Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors.  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,      [PMID:36591642] [10.1080/07391102.2022.2159527]

3. Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang.  (2022)  Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume.  FITOTERAPIA,      [PMID:36270560] [10.1016/j.fitote.2022.105338]

4. Fei Zheng, Na Yang, Shiqi Li, Jingkun Ren, Chengxi Zhang, Yang Hao, Qinjun Sun, Yuying Hao.  (2026)  Bidirectional dual-anchoring buried interface regulates crystallization kinetics of perovskite prepared using two-step method for stable and efficient photovoltaics.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:41579572] [10.1016/j.jcis.2026.139866]

5. Manci Chen, Ting Yu, Xiaoxuan Wang, Wei Wu, Qing Wan, Juan Liu, Ke Li, Jiang Yue, Jinlei Xi, Zheqiong Yang.  (2026)  Drospirenone inhibits neurobehavioral activity in zebrafish larvae by modulating NMDA receptors.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:41621298] [10.1016/j.jhazmat.2026.141269]