Olsalazine Sodium - ≥99% , CAS No.6054-98-4

CAS: 6054-98-4 Cat. No.: O129450 Molecular Weight: 346.2 EC Number: 227-975-7 PubChem CID: 135413505

GRADE & PURITY ≥99%

Synonyms

P17048 | UNII-Y7JEW0XG7I | Benzoic acid, 3,3'-azobis(6-hydroxy-, disodium salt | SW219353-1 | SW219659-1 | 4,4'-Dihydroxyazobenzene-3,3'-dicarboxylic Acid Disodium Salt | FT-0657732 | HMS3264H09 | Y7JEW0XG7I | ZJEFYLVGGFISGT-UHFFFAOYSA-L | 3,3'-azo-bis(6-

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Olsalazine Sodium is a mesalamine dimer.Olsalazine Sodium is a anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.
An anti-inflammatory agent

Specifications

Synonyms

P17048 | UNII-Y7JEW0XG7I | Benzoic acid, 3, 3'-azobis(6-hydroxy-, disodium salt | SW219353-1 | SW219659-1 | 4, 4'-Dihydroxyazobenzene-3, 3'-dicarboxylic Acid Disodium Salt | FT-0657732 | HMS3264H09 | Y7JEW0XG7I | ZJEFYLVGGFISGT-UHFFFAOYSA-L | 3, 3'-azo-bis(6-

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Anti-inflammatory agent. Prodrug of Mesalamine ( Asc 3052 ). Shows anticolitis effects in vivo . Orally active.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488202862
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202862
• Canonical Smiles: C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)[O-])C(=O)O)C(=O)O)[O-].[Na+].[Na+]
• IUPAC Name: disodium;2-carboxy-4-[(3-carboxy-4-oxidophenyl)diazenyl]phenolate
• InChIKey: ZJEFYLVGGFISGT-UHFFFAOYSA-L
• INCHI: 1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2
• Isomeric SMILES: C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)[O-])C(=O)O)C(=O)O)[O-].[Na+].[Na+]
• PubChem CID: 135413505
• Molecular Weight: 346.2

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azobenzenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azobenzenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Azobenzenes
• Alternative Parents: Salicylic acids Benzoic acids Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids Dicarboxylic acids and derivatives Vinylogous acids Azo compounds Carboxylic acid salts Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Hydrocarbon derivatives Organic oxides Organic sodium salts Organic zwitterions Organooxygen compounds Organopnictogen compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Azobenzene - Hydroxybenzoic acid - Salicylic acid or derivatives - Salicylic acid - Benzoic acid or derivatives - Benzoic acid - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Benzenoid - Vinylogous acid - Azo compound - Carboxylic acid salt - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Carboxylic acid derivative - Carboxylic acid - Organic alkali metal salt - Organic zwitterion - Organonitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organic sodium salt - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organic salt - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as azobenzenes. These are organonitrogen aromatic compounds that contain a central azo group, where each nitrogen atom is conjugated to a benzene ring.
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water, and DMSO.
• Sensitivity: light sensitive;Moisture sensitive
• Melt Point(°C): 294 °C(dec.)
• Molecular Weight: 346.200 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 346.018 Da
• Monoisotopic Mass: 346.018 Da
• Topological Polar Surface Area: 145.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 415.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Jiaying Li, Yuji Pu, Sai Li, Bin He, Jianlin Chen.  (2023)  Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment.  BIOMACROMOLECULES,      [PMID:37068182] [10.1021/acs.biomac.3c00146]

2. Qiqi Sun, Jun Chen, Quan Zhao, Ziyun He, Lei Tang, Yuji Pu, Bin He.  (2023)  Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:37068716] [10.1016/j.ijpharm.2023.122962]

3. Yifei Wang, Yaning Xia, Mengyang Zhou, Yong Zhang, Jingliang Cheng, Yupeng Shi.  (2025)  An orally biological chemotaxis-guided hypoxia-responsive biomimetic microcapsules for visualizing multi-faceted synergistic therapy of inflammatory bowel disease.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.160203]