Oxyphenisatin acetate - 10mM in DMSO , CAS No.115-33-3

CAS: 115-33-3 Cat. No.: O656613 Molecular Weight: 401.41 PubChem CID: 8269

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Oxyphenisatin acetate, the pro-agent of oxyphenisatin, is used to be a laxative.

In Vitro

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Oxyphenisatin acetate, the pro-agent of oxyphenisatin, is used to be a laxative.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• ALogP: 3.5

Names and Identifiers

• Isomeric SMILES: CC(=O)OC1=CC=C(C=C1)C2(C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)OC(=O)C
• PubChem CID: 8269
• Molecular Weight: 401.41