Palmitoyl-L-carnitine Hydrochloride - ≥98% , CAS No.18877-64-0

CAS: 18877-64-0 Cat. No.: P305271 Molecular Weight: 436.1 EC Number: 242-642-6 PubChem CID: 167759

GRADE & PURITY ≥98%

Synonyms

1-Propanaminium,3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-,chloride(1:1),(2R)- | (R)-(3-Carboxy-2-((1-oxohexadecyl)oxy)propyl)trimethylammonium chloride | (R)-3-carboxy-N,N,N-trimethyl-2-(palmitoyloxy)propan-1-aminium chloride | O-Palmitoyl-L-carn

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

Specifications

Synonyms

1-Propanaminium, 3-carboxy-N, N, N-trimethyl-2-[(1-oxohexadecyl)oxy]-, chloride(1:1), (2R)- | (R)-(3-Carboxy-2-((1-oxohexadecyl)oxy)propyl)trimethylammonium chloride | (R)-3-carboxy-N, N, N-trimethyl-2-(palmitoyloxy)propan-1-aminium chloride | O-Palmitoyl-L-carn

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Protein kinase inhibitor. Increases erythroid colony formation in vitro . Active in vivo and in vitro .

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504757608
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757608
• Canonical Smiles: CCCCCCCCCCCCCCCC(=O)OC(CC(=O)O)C[N+](C)(C)C.[Cl-]
• IUPAC Name: [(2R)-3-carboxy-2-hexadecanoyloxypropyl]-trimethylazanium;chloride
• InChIKey: GAMKNLFIHBMGQT-ZMBIFBSDSA-N
• INCHI: 1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
• Isomeric SMILES: CCCCCCCCCCCCCCCC(=O)O[C@H](CC(=O)O)C[N+](C)(C)C.[Cl-]
• Alternate CAS: Free Base: 45297-69-6
• PubChem CID: 167759
• Molecular Weight: 436.1

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acid esters

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acid esters
• Intermediate Tree Nodes: Not available
• Direct Parent: Acyl carnitines
• Alternative Parents: Dicarboxylic acids and derivatives Tetraalkylammonium salts Carboxylic acid esters Carboxylic acids Organopnictogen compounds Organic oxides Organic chloride salts Hydrocarbon derivatives Carbonyl compounds Amines
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Acyl-carnitine - Dicarboxylic acid or derivatives - Tetraalkylammonium salt - Quaternary ammonium salt - Carboxylic acid ester - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic chloride salt - Organic salt - Organooxygen compound - Organonitrogen compound - Carbonyl group - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as acyl carnitines. These are organic compounds containing a fatty acid with the carboxylic acid attached to carnitine through an ester bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Methanol (Slightly), Water (Slightly, Heated)
• Sensitivity: Heat Sensitive；moisture sensitive
• Melt Point(°C): 178°C(lit.)
• Molecular Weight: 436.100 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 20
• Exact Mass: 435.312 Da
• Monoisotopic Mass: 435.312 Da
• Topological Polar Surface Area: 63.600 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 404.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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