Pamidronate disodium salt hydrate - ≥97% , CAS No.57248-88-1

CAS: 57248-88-1 Cat. No.: P129944 Molecular Weight: 279.03 (anhydrous basis) EC Number: 260-647-1

GRADE & PURITY ≥97%

Synonyms

CGP-23339AE | DISODIUM DIHYDROGEN (3-AMINO-1-HYDROXYPROPYLIDENE)DIPHOSPHONATE | BCP22745 | Nitrocardiol | NSC720699 | GCP-23339A | Pamidronate sodium | Pamidronic acid sodium salt | CGP-23339A | Acetic acid, (m-chlorophenoxy)- | pamidronate disodium monoh

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

A farnesyl diphosphate synthase inhibitor.

Specifications

Synonyms

CGP-23339AE | DISODIUM DIHYDROGEN (3-AMINO-1-HYDROXYPROPYLIDENE)DIPHOSPHONATE | BCP22745 | Nitrocardiol | NSC720699 | GCP-23339A | Pamidronate sodium | Pamidronic acid sodium salt | CGP-23339A | Acetic acid, (m-chlorophenoxy)- | pamidronate disodium monoh

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. Studies suggest that Pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. I

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488184778
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488184778
• Canonical Smiles: C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
• IUPAC Name: disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate
• InChIKey: CEYUIFJWVHOCPP-UHFFFAOYSA-L
• INCHI: 1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;/q;2*+1/p-2
• Isomeric SMILES: C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
• RTECS: SZ6525000
• Molecular Weight: 279.03 (anhydrous basis)
• Reaxy-Rn: 6459607
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6459607&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic phosphonic acids and derivatives
      • Subclass Bisphosphonates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic phosphonic acids and derivatives
• Subclass: Bisphosphonates
• Intermediate Tree Nodes: Not available
• Direct Parent: Bisphosphonates
• Alternative Parents: Organic phosphonic acids 1,3-aminoalcohols Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic zwitterions Organic sodium salts Organic oxides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Bisphosphonate - 1,3-aminoalcohol - Organophosphonic acid - Organic alkali metal salt - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organic sodium salt - Organic salt - Organic zwitterion - Primary amine - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO Water 56 mg/mL Ethanol
• Sensitivity: Heat Sensitive
• Molecular Weight: 279.030 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 278.965 Da
• Monoisotopic Mass: 278.965 Da
• Topological Polar Surface Area: 167.000 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 238.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Xuexiao Li, Binyan Zhong, Nan Jiang, Jintao Huang, Di Hu, Ruoran Zhou, Jianfeng Zeng, Wenmiao Shu, Guangxin Duan, Shuwang Wu, Ling Wen.  (2025)  Disphosphate based hydrogel microspheres for targeted transarterial radioembolization and chemoembolization therapies.  Journal of Advanced Research,      [PMID:40998256] [10.1016/j.jare.2025.09.044]