PCS1055 dihydrochloride - ≥98% , CAS No.361979-40-0

CAS: 361979-40-0 Cat. No.: P1431927 Molecular Weight: 485.49 PubChem CID: 132470896

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC 50 of 18.1 nM and a K d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [ 3 H]-NMS binding to the M4 receptor with a K i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC 50 s of 22 nM and 120 nM for electric eel and human AChE , respectively.

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1CC2=CC=CC=C2C3=NN=C(C=C3C1)NCCC4CCN(CC4)CC5=CC=CC=C5.Cl.Cl
• IUPAC Name: N-[2-(1-benzylpiperidin-4-yl)ethyl]-3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-amine;dihydrochloride
• InChIKey: VSCSFYDNGYAWKG-UHFFFAOYSA-N
• INCHI: 1S/C27H32N4.2ClH/c1-2-7-22(8-3-1)20-31-17-14-21(15-18-31)13-16-28-26-19-24-11-6-10-23-9-4-5-12-25(23)27(24)30-29-26;;/h1-5,7-9,12,19,21H,6,10-11,13-18,20H2,(H,28,29);2*1H
• PubChem CID: 132470896
• Molecular Weight: 485.49