Quinidine Sulfate - 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.6591-63-5, Sodium channel alpha subunit blocker

CAS: 6591-63-5 Cat. No.: Q425325 Molecular Weight: 782.94 Beilstein Registry Number: 23(2)415 EC Number: 678-472-8 PubChem CID: 656862
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GRADE & PURITY 10mM in DMSO
Synonyms
Quinidine sulfate dihydrate|6591-63-5|Quinidine sulfate|Cin-Quin|Quinidine sulfate hydrate|Quinidex Extentabs|quinidine sulphate dihydrate|Quinidex|Quinora|Quinidine sulphate|Quinidine, sulfate, hydrate (2:1:2)|Quinidine sulfate salt dihydrate|J13S2394HE|
Storage
Protected from light,Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
Q425325-1ml
1

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
Quinidine sulfate dihydrate | 6591-63-5 | Quinidine sulfate | Cin-Quin | Quinidine sulfate hydrate | Quinidex Extentabs | quinidine sulphate dihydrate | Quinidex | Quinora | Quinidine sulphate | Quinidine, sulfate, hydrate (2:1:2) | Quinidine sulfate salt dihydrate | J13S2394HE |
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Quinidine sulfate dihydrate is an antiarrhythmic agent and an effective K + channel blocker with an IC50 value of 19.9 μm. Quinidine sulfate dihydrate is an effective and selective cytochrome P450DB (cytochrome P450DB) inhibitor, which can also be used in
Storage
Protected from light, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
BLOCKER
Mechanism of action
Sodium channel alpha subunit blocker
Names and Identifiers
Canonical SmilesCOC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
IUPAC Name(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;dihydrate
InChIKeyZHNFLHYOFXQIOW-AHSOWCEXSA-N
INCHI1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19+,20-;;;/m00.../s1
Isomeric SMILES COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.O.O.OS(=O)(=O)O
WGK Germany 3
RTECS VA5605000
PubChem CID 656862
Molecular Weight 782.94
Beilstein 23(2)415

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassAlkaloids and derivatives
ClassCinchona alkaloids
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentCinchona alkaloids
Alternative Parents 4-quinolinemethanols  Quinuclidines  Anisoles  Alkyl aryl ethers  Aralkylamines  Pyridines and derivatives  Piperidines  Organic sulfuric acids  Heteroaromatic compounds  Trialkylamines  1,2-aminoalcohols  Secondary alcohols  Azacyclic compounds  Hydrocarbon derivatives  Aromatic alcohols  Organic oxides  Organopnictogen compounds  
Molecular FrameworkNot available
Substituents Cinchonan-skeleton - 4-quinolinemethanol - Quinoline - Anisole - Quinuclidine - Alkyl aryl ether - Sulfuric acid - Aralkylamine - Benzenoid - Pyridine - Piperidine - Heteroaromatic compound - Organic sulfuric acid or derivatives - 1,2-aminoalcohol - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Organoheterocyclic compound - Azacycle - Ether - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Alcohol - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Organic oxide - Aromatic alcohol - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as cinchona alkaloids. These are alkaloids structurally characterized by the presence of the cinchonan skeleton, which consists of a quinoline linked to an azabicyclo[2.2.2]octane moiety.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP2D6 Tclin Cytochrome P450 2D6 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INPP5D Tbio Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (17 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityLight sensitive.
Melt Point(°C)212-214°C
Molecular Weight782.900 g/mol
XLogP3
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count14
Rotatable Bond Count8
Exact Mass782.356 Da
Monoisotopic Mass782.356 Da
Topological Polar Surface Area176.000 Ų
Heavy Atom Count55
Formal Charge0
Complexity538.000
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count5
Documents & Articles
Solution Calculators
Reviews

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