Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 26 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
| Isomeric SMILES | COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O |
|---|---|
| Molecular Weight | 302.28 |
| Reaxy-Rn | 309850 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=309850&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 227-232° C |
|---|
| 1. Siqi Zhao, Yanzi Nan, Runyu Yao, Langhong Wang, Xinan Zeng, Rana Muhammad Aadil, Muhammad Asim Shabbir. (2023) Antibacterial Activity and Transcriptomic Analysis of Hesperetin against Alicyclobacillus acidoterrestris Vegetative Cells. Foods, 12 (17): (3276). [PMID:37685209] [10.3390/foods12173276] |
| 2. Zhi Hu, Shucheng Liu, Nana Tang, Xuan Zhang, Jianming Pan. (2023) Hierarchically porous MOFs self-supporting copolymers for ultrafast transport and precise recognition of flavonoids: A triple interfacial crosslinking strategy based on microreactors. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2023.124819] |
| 3. Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao. (2023) Impact of dietary plant flavonoids on 7,8-dihydroxyflavone transepithelial transport in human intestinal Caco-2 cells. Food Science & Nutrition, [PMID:37970375] [10.1002/fsn3.3581] |
| 4. Shucheng Liu, Zhi Hu, Xingchen Yan, Senbai Geng, Xian Zhao, Hongxiang Ou, Jianming Pan. (2023) Separation and purification of target flavonoids using covalently connected MOFs@boronic acid-functionalized-COFs magnetic hybrids: Precise identification and enhanced stability. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2023.124061] |
| 5. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, [PMID:36870150] [10.1016/j.foodchem.2023.135801] |
| 6. Xinyue Hong, Xiaoqiao Luo, Langhong Wang, Deming Gong, Guowen Zhang. (2023) New Insights into the Inhibition of Hesperetin on Polyphenol Oxidase: Inhibitory Kinetics, Binding Characteristics, Conformational Change and Computational Simulation. Foods, 12 (4): (905). [PMID:36832979] [10.3390/foods12040905] |
| 7. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong. (2023) Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation. Frontiers in Microbiology, [PMID:36819019] [10.3389/fmicb.2023.1092729] |
| 8. Chun Xiao Li, Fu Rong Wang, Bing Zhang, Ze Yuan Deng, Hong Yan Li. (2023) Stability and antioxidant activity of phenolic compounds during in vitro digestion. JOURNAL OF FOOD SCIENCE, 88 (2): (696-716). [PMID:36617678] [10.1111/1750-3841.16440] |
| 9. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2022) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, [PMID:36618100] [10.1016/j.crfs.2022.100424] |
| 10. Meilin Xu, Lunzhao Yi, Dabing Ren, Boyan Li. (2022) Mass defect filtering combined with molecular networking to profile flavonoids in citrus fruit based on liquid chromatography-high resolution mass spectrometry platform: Citrus sinensis (L.) Osbeck as a case study. JOURNAL OF CHROMATOGRAPHY A, [PMID:36375218] [10.1016/j.chroma.2022.463640] |
| 11. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2022) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, [PMID:] [10.1016/j.resconrec.2022.106722] |
| 12. Lu Youluan, Mu Xinwei, Liu Yaopeng, Shi Zhen, Zheng Yin, Huang Wensheng, Lou Fangming. (2022) Biomass porous carbon prepared by endogenous template for electrochemical sensing of hesperetin. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 33 (14): (11446-11454). [PMID:] [10.1007/s10854-022-08117-9] |
| 13. Haihua Jiang, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang. (2021) Effects of interaction between hesperetin/hesperidin and glutenin on the structure and functional properties of glutenin. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2021.112983] |
| 14. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma. (2021) Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles. JOURNAL OF CHROMATOGRAPHY A, [PMID:33975082] [10.1016/j.chroma.2021.462189] |
| 15. Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai, Hong-Guang Xie. (2020) Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood. DRUG METABOLISM AND DISPOSITION, 48 (10): (966-971). [PMID:31900255] [10.1124/dmd.119.089193] |
| 16. Yan Jin Gao, Wei Jie Fu, Jia Liu, Yi Juan Chen, Guang Hui Dai. (2020) Morphological changes of Podosphaera xanthii and induced biochemical defenses of cucumber after treated by (+)-(S)-ar-turmerone. PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, [PMID:] [10.1016/j.pmpp.2020.101524] |
| 17. Chengyun He, Xiaoling Liu, Zhaojing Jiang, Sheng Geng, Hanjun Ma, Benguo Liu. (2019) Interaction Mechanism of Flavonoids and α-Glucosidase: Experimental and Molecular Modelling Studies. Foods, 8 (9): (355). [PMID:31438605] [10.3390/foods8090355] |
| 18. Qian Liu, Hai-Long Wu, Zhi Liu, Rong Xiao, Tong Wang, Yong Hu, Yu-Jie Ding, Ru-Qin Yu. (2018) Chemometrics-assisted HPLC-DAD as a rapid and interference-free strategy for simultaneous determination of 17 polyphenols in raw propolis. Analytical Methods, 10 (46): (5577-5588). [PMID:] [10.1039/C8AY01986J] |
| 19. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2016) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, [PMID:28159264] [10.1016/j.foodchem.2016.12.001] |
| 20. Junjun Wu, Lu Wang, Qinqin Wang, Lina Zou, Baoxian Ye. (2015) The novel voltammetric method for determination of hesperetin based on a sensitive electrochemical sensor. TALANTA, [PMID:26838382] [10.1016/j.talanta.2015.12.026] |
| 21. Kitty S.C. Tang, Izabela Konczak, Jian Zhao. (2015) Identification and quantification of phenolics in Australian native mint (Mentha australis R. Br.). FOOD CHEMISTRY, [PMID:26304400] [10.1016/j.foodchem.2015.07.032] |
| 22. Jiafei Qian, Chuanhong Ren, Fan Wang, Yunlin Cao, Yan Guo, Xiaoyong Zhao, Yilong Liu, Changqing Zhu, Xiaoying Li, Hongxia Xu, Junwei Chen, Kunsong Chen, Xian Li. (2025) Genome-wide identification of UDP-glycosyltransferases involved in flavonol glycosylation induced by UV-B irradiation in Eriobotrya japonica. PLANT PHYSIOLOGY AND BIOCHEMISTRY, [PMID:39805168] [10.1016/j.plaphy.2025.109481] |
| 23. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du. (2025) Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum. PLANT JOURNAL, 121 (3): (e17248). [PMID:39935137] [10.1111/tpj.17248] |
| 24. Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li. (2025) Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C. Food Frontiers, 6 (2): (1058-1078). [PMID:] [10.1002/fft2.70002] |
| 25. Yu Wang, Jie Hua Xu, Fei Yu, Cheng Chen, Kai Hao, Zhe Zhao. (2025) Hesperetin as a potent antiviral agent against channel catfish virus by interfering with viral internalization and early replication. Aquaculture Reports, [PMID:] [10.1016/j.aqrep.2025.103228] |
| 26. Peng Zhao, Chong-Chao Zhong, Nermeen Abu-Elala, Yu-Chen Zhou, Zhi-Wei Hao, Zhi Luo, Xiao-Ying Tan. (2026) Dietary hesperetin mitigates high-fat-induced growth suppression, intestinal lipid accumulation, oxidative stress, and inflammation in largemouth bass (Micropterus salmoides). AQUACULTURE, [PMID:] [10.1016/j.aquaculture.2026.743966] |
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