(Rac)-WAY-161503 - ≥99% , CAS No.75704-24-4

CAS: 75704-24-4 Cat. No.: W649483 Molecular Weight: 272.13 PubChem CID: 21976692

GRADE & PURITY ≥99%

Synonyms

8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE | BLA69522 | DTXSID201030018 | C13575 | WAY161503 hydrochloride | 1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro- | HY-103138 | SR-01000597762

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT 2C receptor agonist with a K i of 4 nM and an EC 50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT 2C than 5-HT 2A and 5-HT 2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.

In Vivo

(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT 2C/2B antagonist SER-082 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT 2C/2B antagonist SER-082.

Form:Solid

Specifications

Synonyms

8, 9-DICHLORO-2, 3, 4, 4A-TETRAHYDRO-1H-PYRAZINO[1, 2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE | BLA69522 | DTXSID201030018 | C13575 | WAY161503 hydrochloride | 1H-Pyrazino[1, 2-a]quinoxalin-5(6H)-one, 8, 9-dichloro-2, 3, 4, 4a-tetrahydro- | HY-103138 | SR-01000597762

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT 2C receptor agonist with a K i of 4 nM and an EC 50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT 2C than 5-HT 2A and 5-HT 2B receptors. (Rac)-WAY-161503 has anti-obesity and ant

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl.Cl
• IUPAC Name: 8,9-dichloro-1,2,3,4,4a,6-hexahydropyrazino[1,2-a]quinoxalin-5-one;hydrochloride
• InChIKey: YPNWSZJDAKOUAW-UHFFFAOYSA-N
• INCHI: 1S/C11H11Cl2N3O.ClH/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8;/h3-4,10,14H,1-2,5H2,(H,15,17);1H
• Isomeric SMILES: C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl.Cl
• PubChem CID: 21976692
• Molecular Weight: 272.13

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acid amides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acid amides
• Alternative Parents: Beta amino acids and derivatives Dialkylarylamines Piperazines Benzenoids Aryl chlorides Secondary carboxylic acid amides Lactams Dialkylamines Azacyclic compounds Organochlorides Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-amino acid amide - Beta amino acid or derivatives - Dialkylarylamine - Tertiary aliphatic/aromatic amine - Aryl chloride - Aryl halide - 1,4-diazinane - Benzenoid - Piperazine - Carboxamide group - Lactam - Tertiary amine - Secondary carboxylic acid amide - Azacycle - Secondary aliphatic amine - Organoheterocyclic compound - Secondary amine - Organohalogen compound - Hydrochloride - Amine - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organochloride - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HTR2A Tclin 5-hydroxytryptamine receptor 2A (0 Activities)

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C (0 Activities)

Discover Target: HTR2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (367.47 mM; Need ultrasonic)
• Molecular Weight: 308.600 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 307.005 Da
• Monoisotopic Mass: 307.005 Da
• Topological Polar Surface Area: 44.400 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 328.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3