RAS/RAS-RAF-IN-1 , CAS No.2447039-81-6

CAS: 2447039-81-6 Cat. No.: R646795 Molecular Weight: 807.98

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a K D of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity

In Vitro

RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC 50 of 0.5 μΜ-5.0 μΜ for BRAF-GTP-KRAS-G12C disruption and has an IC 50 of 1.0 μΜ-10 μΜ for pERK inhibition in H358 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Ras RAF

Specifications

Biochemical and Physiological Mechanisms

RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a K D of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity.

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC(C)(C1=CN(CC(C)(COC([C@@](CCC2)([H])NN2C3=O)=O)C)C4=CC(C5=CC(O)=CC(C[C@@H]3NC([C@H](C(C)C)N(C)C([C@@H](CC6)CN6C(C=C)=O)=O)=O)=C5)=CC=C41)C#N
• Molecular Weight: 807.98

Chemical and Physical Properties

• Solubility: DMSO : 200 mg/mL (247.53 mM; Need ultrasonic)