Ruthenium Red - ≥95% , CAS No.11103-72-3

CAS: 11103-72-3 Cat. No.: R100832 Molecular Weight: 786.35 EC Number: 802-133-7 PubChem CID: 16218584

GRADE & PURITY ≥95%

Synonyms

Ammoniated ruthenium oxychloride | Ruthenium oxychloride ammoniated | Tetraamminechlorohydroxoruthenium(III) chloride | Ruthenium(III) chloride oxide Ammoniated

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Ruthenium red hinders cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to impede neurotransmitter release.In addition , Ruthenium red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Ruthenium red is an inhibitor of CaM and Troponin C.Ruthenium red is an inhibitor of Calcium Channel Protein, SERCA and TRPV.
A voltage-sensitive calcium channel inhibitor

Specifications

Synonyms

Ammoniated ruthenium oxychloride | Ruthenium oxychloride ammoniated | Tetraamminechlorohydroxoruthenium(III) chloride | Ruthenium(III) chloride oxide Ammoniated

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Ca 2+ signaling inhibitor. Inhibits mitochondrial Ca 2+ uniporter, Ca 2+ -ATPase, troponin C and calmodulin. Blocks intracellular Ca 2+ release by ryanodine receptor from internal stores. Attenuates capsaicin-induced cation channel opening.

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504768353
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768353
• Isomeric SMILES: N.N.N.N.N.N.N.N.N.N.N.N.N.N.O.O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].[Ru+2]
• WGK Germany: 3
• PubChem CID: 16218584
• Molecular Weight: 786.35

Chemical and Physical Properties

• Solubility: Soluble in NH4OH, and water (10 mg/ml).
• Melt Point(°C): >500°C
• Molecular Weight: 790.400 g/mol
• Hydrogen Bond Donor Count: 16
• Hydrogen Bond Acceptor Count: 22
• Rotatable Bond Count: 0
• Exact Mass: 792.918 Da
• Monoisotopic Mass: 789.919 Da
• Topological Polar Surface Area: 16.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 4.900
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 25

XLogP3

References

1. Yonghong Miao, Xiaoxue Sun, Guojun Gao, Xianglei Jia, Hao Wu, Ying Chen, Liyong Huang.  (2019)  Evaluation of (-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction.  TOXICOLOGY IN VITRO,      [PMID:31356857] [10.1016/j.tiv.2019.104592]

2. Feng Hong, Wen-Ting Fan, Wei-Hua Huang, Yan-Ling Liu.  (2026)  A Balloon Electrochemical Sensor for Conformal Interfacing With Intestinal Wall and Real-Time Monitoring of Serotonin Release.  Small,      [PMID:41563114] [10.1002/smll.202506988]