SRI-011381 hydrochloride - ≥99% , CAS No.2070014-88-7

CAS: 2070014-88-7 Cat. No.: S651921 Molecular Weight: 365.94 PubChem CID: 122198132

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects

In Vitro

SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.

Form:Solid

IC50& Target:TGF-beta

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3.Cl
• IUPAC Name: 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea;hydrochloride
• InChIKey: GPNMJVSGNMDOJN-UHFFFAOYSA-N
• INCHI: 1S/C20H31N3O.ClH/c24-20(22-19-9-5-2-6-10-19)23(15-17-7-3-1-4-8-17)16-18-11-13-21-14-12-18;/h1,3-4,7-8,18-19,21H,2,5-6,9-16H2,(H,22,24);1H
• PubChem CID: 122198132
• Molecular Weight: 365.94

Chemical and Physical Properties

• Solubility: DMSO : 33.33 mg/mL (91.08 mM; Need ultrasonic) H2O : 25 mg/mL (68.32 mM; Need ultrasonic)
• Molecular Weight: 365.900 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 365.223 Da
• Monoisotopic Mass: 365.223 Da
• Topological Polar Surface Area: 44.400 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 369.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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