Thalidomide 4'-oxyacetamide-alkylC4-azide - ≥98%(HPLC) , CAS No.2098488-36-7

CAS: 2098488-36-7 Cat. No.: T286858 Molecular Weight: 428.4 PubChem CID: 131704500

GRADE & PURITY ≥98%(HPLC)

Synonyms

Azido-Thalidomide | N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide | Cereblon Ligand-Linker Conjugates 4 | E3 ligase Ligand-Linker Conjugates 18 | Thalidomide-O-amido-C4-N3

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

230

Specifications

Synonyms

Azido-Thalidomide | N-(4-Azidobutyl)-2-[[2-(2, 6-dioxo-3-piperidinyl)-2, 3-dihydro-1, 3-dioxo-1H-isoindol-4-yl]oxy]acetamide | Cereblon Ligand-Linker Conjugates 4 | E3 ligase Ligand-Linker Conjugates 18 | Thalidomide-O-amido-C4-N3

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Click-activated thalidomide; hijacks the brain as a precursor to the E3 ubiquitin ligase component. Azide functional handles are provided at locations known not to significantly affect binding to the brain for fast click coupling to linker/target protein

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCN=[N+]=[N-]
• IUPAC Name: N-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide
• InChIKey: USWFAZSQVLTHHA-UHFFFAOYSA-N
• INCHI: 1S/C19H20N6O6/c20-24-22-9-2-1-8-21-15(27)10-31-13-5-3-4-11-16(13)19(30)25(18(11)29)12-6-7-14(26)23-17(12)28/h3-5,12H,1-2,6-10H2,(H,21,27)(H,23,26,28)
• PubChem CID: 131704500
• Molecular Weight: 428.4

Chemical and Physical Properties

• Molecular Weight: 428.400 g/mol
• XLogP3: 1.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 428.144 Da
• Monoisotopic Mass: 428.144 Da
• Topological Polar Surface Area: 136.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 810.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1