Trifluridine (NSC 75520) - Moligand™, 10mM in DMSO , CAS No.70-00-8

CAS: 70-00-8 Cat. No.: T408444 Molecular Weight: 296.2 EC Number: 200-722-8 PubChem CID: 6256

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 529182, Viroptic, Trifluorothymidine, TFT | α,​α,​α-​trifluoro-thymidine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
In vitro

Trifluridine inhibits proliferations of mouse bone marrow cells and human colorectal carcinoma cells implanted to nude mice dose-dependently. Trifluridine inhibits colony formation of bone marrow cells in a concentration-dependent manner. Trifluridine (FTD) and 2\'-deoxy-5-fluorouridine (FdUrd) are incorporated into DNA with different efficiencies due to differences in the substrate specificities of TK1 and DUT, causing abundant FTD incorporation into DNA. FTD-treated cells shows differing nuclear morphologies compared to FdUrd-treated cells. Trifluridine inhibits proliferations of mouse bone marrow cells and human colorectal carcinoma cells implanted to nude mice dose-dependently.

In vivo

Trifluridine has significantly fewer swabs positive for HSV-1 than the untreated eyes in the infected rabbits. Trifluridine has increased antitumor activity and is incorporated into DNA more effectively than continuously infused Trifluridine in mice. Trifluridine gradually accumulates in tumor cell DNA, in a TPI-independent manner, and significantly delays tumor growth and prolonged survival in mice, compared to treatment with 5-FU derivatives. Trifluridine results in significantly lower viral titers, fewer HSV-1-positive eyes/total during the treatment period, lower keratitis scores, fewer eyes with keratitis/total, and a shorter time to resolution of keratitis in the New Zealand rabbit ocular model.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 529182, Viroptic, Trifluorothymidine, TFT | α, ​α, ​α-​trifluoro-thymidine

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• ALogP: -0.5

Names and Identifiers

• Isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
• RTECS: XP2087500
• Alternate CAS: 70-00-8
• PubChem CID: 6256
• MeSH Entry Terms: 2'-deoxy-5-(trifluoromethyl)uridine;5 Trifluoromethyl 2' deoxyuridine;5-Trifluoromethyl-2'-deoxyuridine;TFT Ophtiole;Triflumann;Trifluoridine;Trifluorothymidine;Trifluridine;Viromidin;Virophta;Viroptic
• Molecular Weight: 296.2
• Reaxy-Rn: 568095

Chemical and Physical Properties

• Specific Rotation[α]: +47.0 ～ +53.0°(C=1,H2O)
• Melt Point(°C): 189°C

References

1. Huiqun Huang, Hongyuan Huang, Jie Yang, Huan Yang, Jing Dai, Zhuo Li, Wen Yao, Xinrong Guo.  (2024)  Synthesis of P, N-dopped carbon nanosheets for highly sensitive fluorescence analysis of nitrofuran antibiotics in fish.  FOOD CHEMISTRY,      [PMID:39024887] [10.1016/j.foodchem.2024.140445]