UMB298 - 10mM in DMSO , CAS No.2266569-73-5

CAS: 2266569-73-5 Cat. No.: U655992 Molecular Weight: 479.01 PubChem CID: 137409212

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor

In Vitro

UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth. UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MOLM13 and MM cells Concentration: 0.01~10 μM Incubation Time: 50 days Result: Inhibited cells growth. Western Blot AnalysisCell Line: MOLM13 cells Concentration: 1~10 μM Incubation Time: 2 hours Result: Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. RT-PCRCell Line: MOLM13 cells Concentration: 3 μM Incubation Time: 2 hours Result: Down-regulated MYC expression.

IC50& Target:BRD4 5193 nM (IC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC1=C(C(=NO1)C)C2=CC3=NC(=C(N3C=C2)NC4CCCCC4)CCC5=CC(=C(C=C5)OC)Cl
• PubChem CID: 137409212
• Molecular Weight: 479.01