VH 032 amide-PEG3-acid - ≥95%(HPLC) , CAS No.2140807-42-5

CAS: 2140807-42-5 Cat. No.: V286800 Molecular Weight: 662.79 PubChem CID: 132020301

GRADE & PURITY ≥95%(HPLC)

Synonyms

VH 032 - linker 4 | (S)-15-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-16,16-dimethyl-13-oxo-4,7,10-trioxa-14-azaheptadecanoic acid,(S,R,S)-AHPC-PEG3-propionic acid | (S, R, S)-AHPC-PEG3-acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Overview

Product description
VH 032 amide-PEG3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

Specifications

Synonyms

VH 032 - linker 4 | (S)-15-((2S, 4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-16, 16-dimethyl-13-oxo-4, 7, 10-trioxa-14-azaheptadecanoic acid, (S, R, S)-AHPC-PEG3-propionic acid | (S, R, S)-AHPC-PEG3-acid

Specifications & Purity

≥95%(HPLC)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%(HPLC)

Names and Identifiers

• Pubchem Sid: 528767623
• Canonical Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCOCCC(=O)O)O
• IUPAC Name: 3-[2-[2-[3-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]propanoic acid
• InChIKey: YHEJFYORSLEJKX-BEYSDYMESA-N
• INCHI: 1S/C32H46N4O9S/c1-21-28(46-20-34-21)23-7-5-22(6-8-23)18-33-30(41)25-17-24(37)19-36(25)31(42)29(32(2,3)4)35-26(38)9-11-43-13-15-45-16-14-44-12-10-27(39)40/h5-8,20,24-25,29,37H,9-19H2,1-4H3,(H,33,41)(H,35,38)(H,39,40)/t24-,25+,29-/m1/s1
• PubChem CID: 132020301
• Molecular Weight: 662.79

Chemical and Physical Properties

• Sensitivity: Moisture sensitive