10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB) , with antisecretory activity. Vonoprazan Fumarate inhibits H + ,K + -ATPase activity in porcine gastric microsomes with an IC 50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease
In Vitro
Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H + ,K + -ATPase activity in a concentration-dependent manner. Vonoprazan does not inhibit Na + ,K + -ATPase activity, even at concentrations 500 times higher than their IC 50 values against gastric H + ,K + -ATPase activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (2DG, 200 mg/kg s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male 7- or 8-week-old Sprague-Dawley ratDosage: 0.5, 1, 2, and 4 mg/kg Administration: Oral administration Result: Inhibited basal gastric acid secretion in a dose-dependent manner.
IC50& Target:IC50: 19 nM (porcine gastric H + ,K + -ATPase, at pH 6.5)
| Isomeric SMILES | CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=C/C(=O)O)\C(=O)O |
|---|---|
| Alternate CAS | 1260141-27-2,881681-01-2 |
| PubChem CID | 45375887 |
| MeSH Entry Terms | 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine;TAK 438;TAK-438;TAK438;Vonoprazan |
| Molecular Weight | 461.5 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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