Zalcitabine - Moligand™, 10mM in DMSO , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.7481-89-2, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 7481-89-2 Cat. No.: Z408778 Molecular Weight: 211.22 Beilstein Registry Number: 654956 EC Number: 620-762-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 606170, Ro 24-2027/000 | 2',​3'-​dideoxy-cytidine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Zalcitabine Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 606170, Ro 24-2027/000 | 2', ​3'-​dideoxy-cytidine

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Product Properties

• ALogP: -1.3

Names and Identifiers

• Isomeric SMILES: C1C[C@@H](O[C@@H]1CO)N2C=CC(=NC2=O)N
• WGK Germany: 3
• RTECS: HA3870000
• Molecular Weight: 211.22
• Beilstein: 654956
• Reaxy-Rn: 24724594
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24724594&ln=

Associated Targets(Human)

CXCR4 Tclin C-X-C chemokine receptor type 4 (1 Activities)

Discover Target: CXCR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Specific Rotation[α]: +75.0 to +80.0°(C=1, H2O)
• Melt Point(°C): 209°C

References

1. Sizhu Tian, Xuwen Li, Jia Jiang, Li Tang, Hanqi Zhang, Yong Yu, Ziwei Zhang.  (2021)  Highly sensitive detection of rabbit IgG by electron spin resonance using CuS nanoparticles as probe.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.129835]

2. Li Ming-Qiao, He Yu-Qi, Zhang Meng-Ni, Tang Wan, Tan Ya, Cheng Yue, Yang Mei, Zhao Nan, Li Ling, Yu Si-Rui, Li Ruo-Lan, Pan Qiong, Wu Ming-Yue, Chai Jin.  (2024)  Dronedarone hydrochloride (DH) induces pancreatic cancer cell death by triggering mtDNA-mediated pyroptosis.  Cell Death & Disease,  15  (10): (1-10).  [PMID:39358349] [10.1038/s41419-024-07102-w]