ZC0109 - ≥99% , CAS No.Z658870

CAS: Z658870 Cat. No.: Z658870 Molecular Weight: 591.41

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 ( TrxR1 ) with IC 50 s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis.

Appearance:Solid

IC50& Target:IC50: 50 nM (IDO1), 3.0 μM (TrxR1)

In Vitro:ZC0109 (24 h) inhibits cancer cells with IC 50 s of 3.44 μM (HCT-116), 12.4 μM (CT26), and 10.2 μM (HeLa), respectively. ZC0109 (2.5-10 μM; 24 h) induces ROS accumulation in HCT-116 and HeLa cells. ZC0109 (2.5-10 μM; 24 h) induces apoptosis and

In Vivo:ZC0109 (15, 30, and 60mg/kg; p.o.; once daily for 28 d) reduces Kyn/Trp metabolism in C57BL/6 mice. ZC0109 (60mg/kg; p.o.; once daily for 28 d) decreases tumor growth and increases accumulation and infiltration of T cells in CT-26 cells transplante

Biological Activity:ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 ( TrxR1 ) with IC 50 s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis.

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: O/N=C(C1=NON=C1NCCCC2=NN=C(S2)NC(CC3=CC=C(C=C3)O)=O)\\NC4=CC(Br)=C(C=C4)F
• Molecular Weight: 591.41

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (84.54 mM; ultrasonic and warming and heat to 60°C)