3-Mercaptopropyl(dimethoxy)methylsilane - ≥95%(GC) , CAS No.31001-77-1

CAS: 31001-77-1 Cat. No.: M158195 Molecular Weight: 180.34 Beilstein Registry Number: 2424870 EC Number: 250-426-8

GRADE & PURITY ≥95%(GC)

Synonyms

FS-3987 | AKOS008901366 | 3-(Dimethoxymethylsilyl)-1-propanethiol | J-018222 | gamma-mercaptopropylmethyldimethoxysilane | ?3-Mercaptopropylmethyldimethoxysilane | MFCD00053923 | IKYAJDOSWUATPI-UHFFFAOYSA-N | 3-(Methyldimethoxysilyl)propylmercaptan | C6H1

Storage

Room temperature,Argon charged,Desiccated,Cool

Shipped In

Normal

Overview

(3-Mercaptopropyl)methyldimethoxysilane (MPMDMS) can be used as a silane precursor in the synthesis of:

• Nafion-MPMDMS nanocomposite membranes by sol-gel method.

• MPMDMS functionalized magnetic- polysilsesquioxane (PSSQ) nanoparticles applicable for heavy metal ions adsorption.

• Thiol-organosilica nanoparticles.

Specifications

Synonyms

FS-3987 | AKOS008901366 | 3-(Dimethoxymethylsilyl)-1-propanethiol | J-018222 | gamma-mercaptopropylmethyldimethoxysilane | ?3-Mercaptopropylmethyldimethoxysilane | MFCD00053923 | IKYAJDOSWUATPI-UHFFFAOYSA-N | 3-(Methyldimethoxysilyl)propylmercaptan | C6H1

Specifications & Purity

≥95%(GC)

Storage

Room temperature, Argon charged, Desiccated, Cool

Shipped In

Normal

Purity

≥95%(GC)

Names and Identifiers

• Pubchem Sid: 488193139
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488193139
• Canonical Smiles: CO[Si](C)(CCCS)OC
• IUPAC Name: 3-[dimethoxy(methyl)silyl]propane-1-thiol
• InChIKey: IKYAJDOSWUATPI-UHFFFAOYSA-N
• INCHI: 1S/C6H16O2SSi/c1-7-10(3,8-2)6-4-5-9/h9H,4-6H2,1-3H3
• Isomeric SMILES: CO[Si](C)(CCCS)OC
• WGK Germany: 3
• Molecular Weight: 180.34
• Beilstein: 2424870
• Reaxy-Rn: 2424867
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2424867&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organometallic compounds
    • Class Organometalloid compounds
      • Subclass Organosilicon compounds

• Kingdom: Organic compounds
• Superclass: Organometallic compounds
• Class: Organometalloid compounds
• Subclass: Organosilicon compounds
• Intermediate Tree Nodes: Not available
• Direct Parent: Alkoxysilanes
• Alternative Parents: Silyl ethers Organoheterosilanes Organic metalloid salts Alkylthiols Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Alkoxysilane - Silyl ether - Organoheterosilane - Organic metalloid salt - Alkylthiol - Organic oxygen compound - Hydrocarbon derivative - Organic salt - Organosulfur compound - Organooxygen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as alkoxysilanes. These are organosilicon compounds with the general formula RO[Si](OR')(R'')(R''') (R,R' = organyl; R'',R''' = any atom).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Insoluble in water.
• Sensitivity: air sensitive ；Moisture sensitive
• Refractive Index: 1.45
• Flash Point(°F): 199°F
• Flash Point(°C): 93℃
• Boil Point(°C): 74°C/4mmHg(lit.)
• Molecular Weight: 180.340 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 180.064 Da
• Monoisotopic Mass: 180.064 Da
• Topological Polar Surface Area: 19.500 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 85.800
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3

References

1. Hong Guo, Yuping Liu, Xia Li, Hong Wang, Dengxuan Mao, Liangyin Wei, Xietao Ye, Ding Qu, Jiege Huo, Yan Chen.  (2023)  Magnetic Metal–Organic Framework-Based Nanoplatform with Platelet Membrane Coating as a Synergistic Programmed Cell Death Protein 1 Inhibitor against Hepatocellular Carcinoma.  ACS Nano,      [PMID:37991391] [10.1021/acsnano.3c07885]

2. Cong Gui, Dengxu Wang, Jinfeng Cao, Shengyu Feng.  (2023)  3D Macroporous and Mesoporous Sponge for Selective Pollutant Removal.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.3c02130]

3. Zhenqiang Zhang, Qingyi Xie, Guoliang Zhang, Chunfeng Ma, Guangzhao Zhang.  (2023)  Surface-Enriched Amphiphilic Polysiloxane Coating with Superior Antifouling Ability and Strong Substrate Adhesion.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.3c00199]

4. Xinbo Guo, Ning Li, Yushu Xu, Jianfu Zhao, Fucai Cui, Yimu Chen, Xiaoyan Du, Qinghai Song, Guodong Zhang, Xiao Cheng, Xutang Tao, Zhaolai Chen.  (2023)  Mitigating Surface Deficiencies of Perovskite Single Crystals Enables Efficient Solar Cells with Enhanced Moisture and Reverse-Bias Stability.  ADVANCED FUNCTIONAL MATERIALS,  33  (22): (2213995).  [PMID:] [10.1002/adfm.202213995]

5. Yuehan Qian, Fuhao Dong, Lizhen Guo, Shanling Lu, Xu Xu, He Liu.  (2023)  Self-Healing and Reprocessable Terpene Polysiloxane-Based Poly(thiourethane-urethane) Material with Reversible Thiourethane Bonds.  BIOMACROMOLECULES,      [PMID:36808988] [10.1021/acs.biomac.2c01230]

6. Zhen Yang, Yongping Bai, Binxiao Wei, Yutao Cui, JunHui Huang, Yingying Li, Linghui Meng, Yu Wang.  (2022)  A facile preparation method of UV rapid curing fluorosilicone coatings with good hydrophobicity and excellent corrosion resistance based on thiol-ene click reaction.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2022.107248]

7. Jianqing Peng, Xiaoxia Hu, Shuangqin Fan, Jia Zhou, Shuang Ren, Runbin Sun, Yi Chen, Xiangchun Shen, Yan Chen.  (2022)  Inhibition of Mitochondrial Biosynthesis Using a “Right-Side-Out” Membrane-Camouflaged Micelle to Facilitate the Therapeutic Effects of Shikonin on Triple-Negative Breast Cancer.  Advanced Healthcare Materials,  11  (18): (2200742).  [PMID:35818932] [10.1002/adhm.202200742]

8. Yu Hei, Yang Chen, Qian Li, Zi Mei, Jijia Pan, Siqi Zhang, Chunyang Xiong, Xiaodong Su, Shicheng Wei.  (2021)  Multifunctional Immunoliposomes Enhance the Immunotherapeutic Effects of PD-L1 Antibodies against Melanoma by Reprogramming Immunosuppressive Tumor Microenvironment.  Small,  18  (9): (2105118).  [PMID:34915595] [10.1002/smll.202105118]

9. Hongyan Zhang, Ji Li, Rong Yuan, Yufen Li, Yue Zhang, Xiaoyun Hu, Jiqiang Qu, Yu Chen, Zheran Wang, Mingyu Xia, Dongkai Wang.  (2021)  Augment the efficacy of eradicating metastatic lesions and tumor proliferation in breast cancer by honokiol-loaded pH-sensitive targeted lipid nanoparticles.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:34333303] [10.1016/j.colsurfb.2021.112008]

10. Guo Shiqi, Liang Yanzi, Liu Lanze, Yin Miaomiao, Wang Aiping, Sun Kaoxiang, Li Youxin, Shi Yanan.  (2021)  Research on the fate of polymeric nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size, surface charge and pro-hydrophobics.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-21).  [PMID:33499885] [10.1186/s12951-021-00770-2]

11. Hui Wang, Hui Yu, Yan Wang, Xiaonan Shan, Hong-Yuan Chen, Nongjian Tao.  (2020)  Phase imaging of transition from classical to quantum plasmonic couplings between a metal nanoparticle and a metal surface.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,  117  (30): (17564-17570).  [PMID:32665434] [10.1073/pnas.2006443117]

12. Hongwei Li, Junhui Pan, Chengtao Gao, Mengyu Ma, Liangyu Lu, Yuzhu Xiong, Fuping Dong.  (2019)  Mercapto-Functionalized Porous Organosilica Monoliths Loaded with Gold Nanoparticles for Catalytic Application.  MOLECULES,  24  (23): (4366).  [PMID:31795338] [10.3390/molecules24234366]

13. Hongyun Zhang, Ying Xia, Mingpeng Zhou, Jianyong Zheng, Zhao Wang, Yinjun Zhang.  (2019)  Purification and characterization of a thermoalkaliphilic esterase from Bacillus cereus WZZ006 for enantioselective resolution of indoxacarb intermediate.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:31430490] [10.1016/j.ijbiomac.2019.08.140]

14. Shu Han, Ruiyang Sun, Hong Su, Jing Lv, Huan Xu, Di Zhang, Yuanshan Fu.  (2018)  Delivery of docetaxel using pH-sensitive liposomes based on D-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate: Comparison with PEGylated liposomes.  Asian Journal of Pharmaceutical Sciences,      [PMID:32104468] [10.1016/j.ajps.2018.07.005]

15. Jianming Liang, Caifang Gao, Ying Zhu, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Jue Wang, Weigen Lu, Jianxin Wang.  (2018)  Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery.  ACS Applied Materials & Interfaces,      [PMID:30113810] [10.1021/acsami.8b11782]

16. Cong Gui, Dengxu Wang, Jinfeng Cao, Shengyu Feng.  (2024)  Efficient fabrication of conductive sponges for wearable flexible sensors.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.156251]

17. Yuxiang Tang, Zeliang Wu, Hang Hu, Dianwen Yu, Chaohong Liu, Huiwen Jiang, Wenjing Luo, Heng Mei, Rong Xu, Yu Hu.  (2024)  Indocyanine green-mediated fabrication of urchin-like hydroxyethyl starch nanocarriers for enhanced drug tumor EPR and deep penetration effects.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38795885] [10.1016/j.ijbiomac.2024.132616]

18. Fei Cai, Jinrong Dong, Peng Xie, Hanlong He, Huiyi Yao, Junxian Guo, Zhibo Yan, Li Ma, Tianfeng Chen.  (2025)  Mn-Specific Recognition of Guanidine Drives Selective Inhibition of Complex I.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39977356] [10.1021/acs.jmedchem.4c02904]

19. Xiaomeng Yuan, Xiaoying Liu, Hongjie Li, Shan Peng, Haiqin Huang, Zhe Yu, Limei Chen, Xinlu Liu, Jingkun Bai.  (2024)  pH-Triggered Transformable Peptide Nanocarriers Extend Drug Retention for Breast Cancer Combination Therapy.  Advanced Healthcare Materials,      [PMID:38588449] [10.1002/adhm.202400031]

20. Dengke Li, Qinghao Shi, Fengbing Liang, Dexin Feng.  (2024)  The Green Synthesis of Biodiesel via Esterification in Water Catalyzed by the Phosphotungstic Acid–Functionalized Hydrophobic MCM–41 Catalyst.  Catalysts,  14  (2): (142).  [PMID:] [10.3390/catal14020142]

21. Yuanhao Shen, Xinlei He, Wenjun Meng, Xiaocheng Huang, Pengzhe Cai, Zheng Yang, Weiwei Du, Xinyi Zhang, Yingwu Luo, Junjie Zhao.  (2025)  Visible-Light-Driven Sustainable Chemical Vapor Deposition of Polymer Films and Patterns.  Small,      [PMID:40244112] [10.1002/smll.202502586]