4,4′-Dipyridyl disulfide - ≥98% , CAS No.2645-22-9

CAS: 2645-22-9 Cat. No.: D109419 Molecular Weight: 220.31 Beilstein Registry Number: 21(2)35 EC Number: 220-158-6

GRADE & PURITY ≥98%

Synonyms

Pyridine, 4,4'-dithiobis- | Aldrithiol(TM)-4, 98% | D2477 | Di(4-pyridyl) disulfide | C19H17NO7 | YSWG013 | 4-(4-pyridyldisulfanyl)pyridine | MFCD00006423 | Nedocromil sodium [USAN] | Pyridine, 4,4'-dithiodi- | STK532154 | 4,4-dipyridyldisulfide | 4,4'-di

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

Thiol reagent.Used to modify gold surfaces for protein studies.

Specifications

Synonyms

Pyridine, 4, 4'-dithiobis- | Aldrithiol(TM)-4, 98% | D2477 | Di(4-pyridyl) disulfide | C19H17NO7 | YSWG013 | 4-(4-pyridyldisulfanyl)pyridine | MFCD00006423 | Nedocromil sodium [USAN] | Pyridine, 4, 4'-dithiodi- | STK532154 | 4, 4-dipyridyldisulfide | 4, 4'-di

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504754999
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504754999
• Canonical Smiles: C1=CN=CC=C1SSC2=CC=NC=C2
• IUPAC Name: 4-(pyridin-4-yldisulfanyl)pyridine
• InChIKey: UHBAPGWWRFVTFS-UHFFFAOYSA-N
• INCHI: 1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H
• Isomeric SMILES: C1=CN=CC=C1SSC2=CC=NC=C2
• WGK Germany: 3
• Molecular Weight: 220.31
• Beilstein: 21(2)35
• Reaxy-Rn: 154742
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=154742&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyridines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyridines and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridines and derivatives
• Alternative Parents: Heteroaromatic compounds Organic disulfides Sulfenyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridine - Heteroaromatic compound - Organic disulfide - Azacycle - Sulfenyl compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-member aromatic heterocycle which consists of one nitrogen atom and five carbon atoms.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

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PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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TRPC5 Tchem Short transient receptor potential channel 5 (300 Activities)

Discover Target: TRPC5

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

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Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

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Luciferin 4-monooxygenase (66902 Activities)

Explore this target

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pfk 6-phospho-1-fructokinase (7870 Activities)

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ddn Putative uncharacterized protein (49 Activities)

Discover Target: ddn

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

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NS1 Nonstructural protein 1 (33327 Activities)

Discover Target: NS1

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in 95% Ethanol.
• Sensitivity: Air & Heat Sensitive
• Melt Point(°C): 75-79°C
• Molecular Weight: 220.300 g/mol
• XLogP3: 1.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 220.013 Da
• Monoisotopic Mass: 220.013 Da
• Topological Polar Surface Area: 76.400 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 136.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shanshan Dong, Liumin Fan, Yunfang Ma, Juan Du, Qisen Xiang.  (2021)  Inactivation of polyphenol oxidase by dielectric barrier discharge (DBD) plasma: Kinetics and mechanisms.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2021.111322]

2. Junguang Li, Qisen Xiang, Xiufang Liu, Tian Ding, Xiangsheng Zhang, Yafei Zhai, Yanhong Bai.  (2017)  Inactivation of soybean trypsin inhibitor by dielectric-barrier discharge (DBD) plasma.  FOOD CHEMISTRY,      [PMID:28490106] [10.1016/j.foodchem.2017.03.167]

3. Chen Cheng-Xia, Cui Xili, Xiong Yang-Yang, Lan Pui Ching, Tan Kui, Wei Zhang-Wen, Niu Zheng, Shan Chuan, Yang Lifeng, Ma Shengqian, Su Cheng-Yong.  (2025)  Adaptive metal–organic frameworks with crystalline dynamicity for durable gas separation.  Nature Synthesis,      [PMID:] [10.1038/s44160-025-00911-7]

4. Feitao Fan, Yiting Che, Vadim Efimov, Kuzmin Anton, Shitan Yan, Ting Bian.  (2025)  Hofmann-type MOFs derived small-sized Pt nanoparticles embedded in S, N codoped carbon matrix for enhanced oxygen reduction reaction.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.jelechem.2025.119545]