4-Methylumbelliferyl sulfate potassium salt - ≥99% , CAS No.15220-11-8

CAS: 15220-11-8 Cat. No.: M131130 Molecular Weight: 294.322 Beilstein Registry Number: 3803203 EC Number: 239-272-2

GRADE & PURITY ≥99%

Synonyms

AKOS015914539 | 4-Methylumbelliferyl sulfate potassium salt, 98% | 2H-1-Benzopyran-2-one,4-methyl-7-(sulfooxy)-, potassium salt | AKOS024418738 | 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (1:1) | 4-Methylumbelliferyl sulfate potassium

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

4-Methylumbelliferyl sulfate, potassium salt is a coumarin derivative and highly sensitive fluorescent substrate for monitoring aryl sulfatase activity. This compound is virtually non-fluorescent until cleavage by sulfatase enzymes, then emits blue fluorescence (450 nm) with excitation at 360 nm. This substrate has been used in the discovery of tyrosine sulfotransferase inhibitors, particularly in P-selectin glycoprotein ligand-1 binding. Use of this compound in high-throughput fluorescence based screening led to the discovery of several potent beta-arylsulfotransferase IV (beta-AST-IV) inhibitors.

Specifications

Synonyms

AKOS015914539 | 4-Methylumbelliferyl sulfate potassium salt, 98% | 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt | AKOS024418738 | 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (1:1) | 4-Methylumbelliferyl sulfate potassium

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC1=CC(=O)OC2=C1C=CC(=C2)OS(=O)(=O)[O-].[K+]
• IUPAC Name: potassium;(4-methyl-2-oxochromen-7-yl) sulfate
• InChIKey: CSOCSPXOODWGLJ-UHFFFAOYSA-M
• INCHI: 1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1
• Isomeric SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)OS(=O)(=O)[O-].[K+]
• Molecular Weight: 294.322
• Beilstein: 3803203
• Reaxy-Rn: 3803203
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3803203&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Coumarins and derivatives

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Coumarins and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Coumarins and derivatives
• Alternative Parents: Arylsulfates 1-benzopyrans Pyranones and derivatives Sulfuric acid monoesters Benzenoids Heteroaromatic compounds Lactones Oxacyclic compounds Organooxygen compounds Organic potassium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Coumarin - Benzopyran - Arylsulfate - 1-benzopyran - Pyranone - Pyran - Sulfuric acid monoester - Sulfate-ester - Benzenoid - Sulfuric acid ester - Heteroaromatic compound - Organic sulfuric acid or derivatives - Lactone - Oxacycle - Organic alkali metal salt - Organoheterocyclic compound - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Organic potassium salt - Organic oxide - Organic salt - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO, DMF, Methanol and Water
• Sensitivity: Light & Moisture Sensitive
• Molecular Weight: 294.320 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 293.96 Da
• Monoisotopic Mass: 293.96 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 451.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Chencheng Dai, Yiwei Cao, Yiran Xu, Moyuan Li, Guangquan Liu, Sujuan Xu, Nuo Ye, Changxiang Shi, Tiantian Fan, Pengfei Xu, Xuemei Jia.  (2026)  Serum metabolic fingerprinting for diagnosis and therapeutic applications of ovarian endometriosis.  iScience,  29  (3):   [PMID:41743236] [10.1016/j.isci.2026.114887]