10mM in Water for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X 3 and P2X 2/3 receptors , with K i s of 22, 22, 9, and 92 nM for hP2X 3 , rP2X 3 , hP2X 2/3 , and rP2X 2/3 , respectively. A-317491 sodium salt hydrate is highly sele
IC50& Target:P2X3 Receptor
In Vitro:A-317491 potently blocks recombinant human and rat P2X 3 and P2X 2/3 receptor-mediated calcium flux (K i =22-92 nM). A-317491 (1 nM-10 μM) produces a concentration-dependent block of dorsal root ganglion (DRG) currents with an IC 50 of 15 nM. MC
In Vivo:A-317491 (0.1-30mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats. A-317491 (3-30mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17
Biological Activity:A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X 3 and P2X 2/3 receptors , with K i s of 22, 22, 9, and 92 nM for hP2X 3 , rP2X 3 , hP2X 2/3 , and rP2X 2/3 , respectively. A-317491 sodium salt hydrate is highly sele
| Molecular Weight | 606.57 |
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Comprehensive hazard, handling, storage, and regulatory compliance document.
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