10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.
In Vivo
ABT-107 exhibits good bioavailability in mouse (orally, 51.1%; intraperitoneally,100%), rat (orally, 81.2%; intraperitoneally, 100.0%), and monkey (orally, 40.6%; intramuscularly,\n100%), and good CNS penetration in rodents with a brain/plasma ratio of 1 . ABT-107 (0.01-1 μmol/kg i.p., 15 min before sacrifice) produces a dose-dependent increase in ERK1/2 and CREB . ABT-107 (0.01, 0.1, and 1.0 mg/kg i.p.) increases S 9 -GSK3 and decreases p-tau in mouse cortex and hippocampus in mice . ABT-107 (5 mg/kg/day i.p.) infusion attenuates tau hyperphosphorylation in AD transgenic APP-tau mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rats (male Sprague-Dawley; 350-380 g b.wt.) . Dosage: 1, 3 μmol/kg. Administration: I.P. daily for 3 consecutive days. Result: Induced a significant, dose-dependent increase in ACh release by day 3 of repeated administration. Higher doses may be required to evoke ACh release in naive rats not engaged in stimulated, i.e., cognitive-related behavior. Animal Model: Female TAPP (and wild-type littermates) mice . Dosage: 1 mg/kg. Administration: Continuous subcutaneous infusion for 2 weeks. Result: Produced a dose-dependent increase in Ser9 phosphorylation in the cingulate cortex 15 min after acute administration in mice.
| ALogP | 2.6 |
|---|
| Isomeric SMILES | C1CN2CCC1[C@H](C2)OC3=NN=C(C=C3)C4=CC5=C(C=C4)NC=C5 |
|---|---|
| Alternate CAS | 855291-54-2 |
| PubChem CID | 11151363 |
| MeSH Entry Terms | 5-(6-(1-azabicyclo(2,2,2)oct-3-yloxy)pyridazin-3-yl)-1H-indole;ABT 107;ABT-107;ABT107 |
| Molecular Weight | 320.39 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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