Avermectin B1a - ≥95% , CAS No.65195-55-3

CAS: 65195-55-3 Cat. No.: A329452 Molecular Weight: 873.1 EC Number: 265-610-3
AVAILABLE TO ORDER
GRADE & PURITY ≥95%
Synonyms
AKOS027327844 | CHEBI:29534 | Abamectina | AB00918538-03 | Abamectin B1a | Abamectin komponente B1a | WLN: T6O BUTJ FVH | J-519606 | UNII-5E2OT6T2PS | Abamectin B1a 1000 microg/mL in Acetonitrile | Cresyl alpha-toluate, p- | 5-O-Demethylavermectin A1a; Sp
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
A329452-1mg
5
$28.90
5mg
A329452-5mg
3
$76.90
25mg
A329452-25mg
1
$285.90
100mg
A329452-100mg
1
$745.90
500mg
A329452-500mg
1
$2,571.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Avermectin B1a is a macrocyclic lactone that makes up a large component of the anthelimintic Abamectin used to control parasitic nematodes in livestock. Avermectin B1a also acts as an insecticide and acaricide. The avermectins are used commercially as antiparasitic agents in animal health, agriculture and human infections. Research shows that it can activate and inhibit GABA|A|Rα1 (gamma-aminobutyric acidA) receptor function in mammalian brain.

Specifications

Synonyms
AKOS027327844 | CHEBI:29534 | Abamectina | AB00918538-03 | Abamectin B1a | Abamectin komponente B1a | WLN: T6O BUTJ FVH | J-519606 | UNII-5E2OT6T2PS | Abamectin B1a 1000 microg/mL in Acetonitrile | Cresyl alpha-toluate, p- | 5-O-Demethylavermectin A1a; Sp
Specifications & Purity
≥95%
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥95%
Names and Identifiers
Pubchem Sid488195776
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195776
Canonical SmilesCCC(C)C1C(C=CC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
IUPAC Name(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-3,11',13',22'-tetramethylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-2'-one
InChIKeyRRZXIRBKKLTSOM-XPNPUAGNSA-N
INCHI1S/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
Isomeric SMILES CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
Molecular Weight 873.1
Reaxy-Rn 29608163
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29608163&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassMacrolides and analogues
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentMacrolides and analogues
Alternative Parents Disaccharides  O-glycosyl compounds  Ketals  Oxanes  Pyrans  Tertiary alcohols  Tetrahydrofurans  Secondary alcohols  Lactones  Carboxylic acid esters  Oxacyclic compounds  Monocarboxylic acids and derivatives  Dialkyl ethers  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic heteropolycyclic compounds
Substituents Macrolide - Disaccharide - Glycosyl compound - O-glycosyl compound - Ketal - Oxane - Pyran - Tetrahydrofuran - Tertiary alcohol - Secondary alcohol - Carboxylic acid ester - Lactone - Acetal - Carboxylic acid derivative - Organoheterocyclic compound - Dialkyl ether - Ether - Monocarboxylic acid or derivatives - Oxacycle - Organic oxygen compound - Alcohol - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Aliphatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
External Descriptors Macrolides and lactone polyketides
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
HSPD1 Tbio HSP60/HSP10 (366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TST Tchem Thiosulfate sulfurtransferase (144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Artemia salina (1320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oesophagostomum columbianum (45 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calliphoridae (33 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ovis aries (854 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caenorhabditis elegans (1055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Haemonchus contortus (724 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichostrongylus colubriformis (210 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichoplusia ni (986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cooperia oncophora (36 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spodoptera eridania (79 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tetranychus urticae (2600 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Stomoxys calcitrans (84 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichostrongylus axei (45 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Teladorsagia circumcincta (67 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
groL GroEL/GroES (1042 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
groEL 60 kDa chaperonin (64 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
C2318645Certificate of AnalysisJan 19, 2026 A329452
C2318650Certificate of AnalysisJan 19, 2026 A329452
C2318652Certificate of AnalysisJan 19, 2026 A329452
C2318653Certificate of AnalysisJan 19, 2026 A329452
C2318654Certificate of AnalysisJan 19, 2026 A329452
C2318658Certificate of AnalysisJan 19, 2026 A329452
C2318664Certificate of AnalysisJan 19, 2026 A329452
C2318666Certificate of AnalysisJan 19, 2026 A329452
C2318667Certificate of AnalysisJan 19, 2026 A329452
C2318683Certificate of AnalysisJan 19, 2026 A329452
Chemical and Physical Properties
SolubilitySoluble in ethanol, methanol, DMF or DMSO
SensitivityMoisture sensitive
Refractive Index1.571
Molecular Weight873.100 g/mol
XLogP33.800
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count14
Rotatable Bond Count8
Exact Mass872.492 Da
Monoisotopic Mass872.492 Da
Topological Polar Surface Area170.000 Ų
Heavy Atom Count62
Formal Charge0
Complexity1730.000
Isotope Atom Count0
Defined Atom Stereocenter Count20
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds3
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong.  (2023)  Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,      [PMID:38135203] [10.1016/j.etap.2023.104351]
2. Song Lianjun, Wang Youyi, Li Qingyue, Wang Jinkui, Gao Tian, An Zhaohuan, Liu Qinfang, Mao Yexuan, Bu Tong, Huang Xianqing, Ma Yan, Wang Zhanhui, Zhang Xiya.  (2023)  Production of monoclonal antibody against tylosin and tilmicosin with homogeneous cross-reactivity and its application in lateral flow immunoassay.  MICROCHIMICA ACTA,  191  (1): (1-12).  [PMID:38114730] [10.1007/s00604-023-06132-z]
3. Xu Xuhui, Zhou Mengyuan, Xie Kunmei, Zhang Shuai, Ji Xiaomeng, Sun Ying, Li Qiulu, Dong Zibo.  (2023)  Mitigation of avermectin exposure-induced brain tissue damage in carp by quercetin.  FISH PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:37831371] [10.1007/s10695-023-01249-7]
4. Guanglu Wang, Jiajia Guo, Yeyun Ma, Yue Xin, Xiaomeng Ji, Ying Sun, Jian Zhang, Jingquan Dong.  (2023)  Ferulic acid alleviates carp brain damage and growth inhibition caused by avermectin by modulating the Nrf2/Keap1 and NF-κB signaling pathways.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:37945241] [10.1016/j.pestbp.2023.105590]
5. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan.  (2023)  Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway.  FISH PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:37542703] [10.1007/s10695-023-01228-y]
6. Enzhuang Pan, Huizhen Chen, Xinyu Wu, Nana He, Jiajie Gan, Huimiao Feng, Yong Sun, Jingquan Dong.  (2023)  Protective effect of quercetin on avermectin induced splenic toxicity in carp: Resistance to inflammatory response and oxidative damage.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:37248014] [10.1016/j.pestbp.2023.105445]
7. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu.  (2023)  The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.).  PEST MANAGEMENT SCIENCE,      [PMID:36809665] [10.1002/ps.7415]
8. Tianmeng Zhang, Zhuhua Dong, Feixue Liu, Enzhuang Pan, Nana He, Fenfen Ma, Xinyu Wu, Yan Wang, Jingquan Dong.  (2022)  Non-target toxic effects of avermectin on carp spleen involve oxidative stress, inflammation, and apoptosis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:36127050] [10.1016/j.pestbp.2022.105190]
9. Zhiping Che, Xiaolong Guo, Yuanhao Li, Song Zhang, Lina Zhu, Jiaxuan He, Di Sun, Yihao Guo, Yibo Liu, Ruxue Wei, Xiaobo Huang, Shengming Liu, Genqiang Chen, Yuee Tian.  (2022)  Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities.  PEST MANAGEMENT SCIENCE,  78  (8): (3442-3455).  [PMID:35567371] [10.1002/ps.6985]
10. Chan-Yuan YAO, Jin-Yi YANG, Zhen-Lin XU, Hong WANG, Hong-Tao LEI, Yuan-Ming SUN, Yuan-Xin TIAN, Yu-Dong SHEN.  (2018)  Indirect Competitive Enzyme-Linked Immunosorbent Assay for Detection of Tylosin in Milk and Water Samples.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,      [PMID:] [10.1016/S1872-2040(18)61106-5]
11. Mei Hu, Xiaolong Guo, Yuee Tian, Yan Li, Yibo Liu, Xiaobo Huang, Genqiang Chen, Zhiping Che.  (2024)  Synthesis of paeonol hydrazone derivatives and their anti-oomycete, anti-fungal, and nematicidal activities.  PEST MANAGEMENT SCIENCE,      [PMID:39003636] [10.1002/ps.8306]
12. Xiaofang Zhang, Xiaolong Guo, Wanying Yin, Ruiguang Wang, Yuee Tian, Huilu Sun, Shaobin Xu, Shaoyan Shuang, Xiaobo Huang, Genqiang Chen, Zhiping Che.  (2024)  Synthesis, anti-oomycete and anti-fungal activities of novel paeonol ester derivatives containing a schiff base.  NATURAL PRODUCT RESEARCH,      [PMID:39727242] [10.1080/14786419.2024.2426205]
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