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· · COA & SDS available for every product · Same-day shipping on in-stock items Bitopertin - Moligand™, 10mM in DMSO , Glycine transporter 1 inhibitor, CAS No.845614-11-1, Glycine transporter 1 inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO Synonyms
RG1678 | RO4917838 | DISC-1459 | 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone | MFCD18251496 | METHANONE, (4-(3-FLUORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL)-1-PIPERAZINYL)(5-(METHYLSULFONYL)-2-((1S)-2,2,2-TRIFLUORO-1-METHYLETHOXY)PHENYL)- | RO4917838 | RO-4
Shipped In
Dry ice packs + Cold packs
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Why this grade Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview RG1678 (Bitopertin) is a potent and noncompetitive glycine reuptake inhibitor (GlyT1)
Specifications Synonyms
RG1678 | RO4917838 | DISC-1459 | 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone | MFCD18251496 | METHANONE, (4-(3-FLUORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL)-1-PIPERAZINYL)(5-(METHYLSULFONYL)-2-((1S)-2, 2, 2-TRIFLUORO-1-METHYLETHOXY)PHENYL)- | RO4917838 | RO-4
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
RG1678 (Bitopertin) is a potent and noncompetitive glycine reuptake inhibitor (GlyT1). Recent Phase II data shows that RG1678 is effective in reducing the negative symptoms when given in combination with second generation antipsychotics.
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Glycine transporter 1 inhibitor
Product Properties Names and Identifiers Canonical Smiles CC(C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F IUPAC Name [4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone InChIKey YUUGYIUSCYNSQR-LBPRGKRZSA-N INCHI 1S/C21H20F7N3O4S/c1-12(20(23,24)25)35-17-4-3-14(36(2,33)34)10-15(17)19(32)31-7-5-30(6-8-31)18-16(22)9-13(11-29-18)21(26,27)28/h3-4,9-12H,5-8H2,1-2H3/t12-/m0/s1 Isomeric SMILES C[C@@H](C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F Molecular Weight 543.46 Reaxy-Rn 12199870 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12199870&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Diazinanes Subclass Piperazines Intermediate Tree Nodes Not available Direct Parent Pyridinylpiperazines Alternative Parents N-arylpiperazines Benzenesulfonyl compounds Benzamides Phenoxy compounds Phenol ethers Dialkylarylamines Benzoyl derivatives Alkyl aryl ethers Aminopyridines and derivatives Imidolactams Aryl fluorides Tertiary carboxylic acid amides Sulfones Heteroaromatic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides Alkyl fluorides Organofluorides Molecular Framework Aromatic heteromonocyclic compounds Substituents Pyridinylpiperazine - N-arylpiperazine - Benzamide - Benzenesulfonyl group - Benzoic acid or derivatives - Phenoxy compound - Benzoyl - Phenol ether - Dialkylarylamine - Alkyl aryl ether - Aminopyridine - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Pyridine - Imidolactam - Benzenoid - Tertiary carboxylic acid amide - Sulfonyl - Sulfone - Heteroaromatic compound - Carboxamide group - Azacycle - Ether - Carboxylic acid derivative - Organosulfur compound - Organohalogen compound - Organofluoride - Hydrocarbon derivative - Alkyl halide - Organic oxide - Alkyl fluoride - Organic nitrogen compound - Amine - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Molecular Weight 543.500 g/mol XLogP3 4.000 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 13 Rotatable Bond Count 5 Exact Mass 543.106 Da Monoisotopic Mass 543.106 Da Topological Polar Surface Area 88.200 Ų Heavy Atom Count 36 Formal Charge 0 Complexity 872.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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