Caspofungin (MK-0991) Acetate - 10mM in Water , 1,3-beta-glucan synthase inhibitor, CAS No.179463-17-3, 1,3-beta-glucan synthase inhibitor

CAS: 179463-17-3 Cat. No.: C408660 Molecular Weight: 1213.42 EC Number: 605-859-0 PubChem CID: 6850808

GRADE & PURITY 10mM in Water

Synonyms

L-743872 | Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Caspofungin (MK-0991) Acetate Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.
In vitro

Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0)

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

L-743872 | Pneumocandin B0, 1-[(4R, 5S)-5-[(2-aminoethyl)amino]-N2-[(10R, 12S)-10, 12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2)

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1, 3-glucan synthase inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

1, 3-beta-glucan synthase inhibitor

Names and Identifiers

• Isomeric SMILES: CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
• WGK Germany: 3
• RTECS: TP8046500
• PubChem CID: 6850808
• Molecular Weight: 1213.42

References

1. Longfei Yang, Xiaonan Wang, Zhiming Ma, Yujie Sui, Xin Liu.  (2024)  Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  28  (9): (e18354).  [PMID:38686557] [10.1111/jcmm.18354]