(-)-Catechin Gallate - ≥98%(HPLC) , CAS No.130405-40-2

CAS: 130405-40-2 Cat. No.: C131962 Molecular Weight: 442.37 EC Number: 621-447-3
AVAILABLE TO ORDER
GRADE & PURITY ≥98%(HPLC)
Synonyms
(?)-Catechin gallate | (-)-Catechin gallate | C22H18O10 | S00277 | (-)-Catechin gallate(CG) | (2S,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate | AC-34201 | ent-Catechin 3-O-gallate | Benzoic acid, 3,4,5-trihydroxy-, 2-(3,
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1mg
C131962-1mg
3

$114.90

$136.90
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5mg
C131962-5mg
3
$301.90
10mg
C131962-10mg
2
$486.90
25mg
C131962-25mg
3
$1,095.90
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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 15 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

(-) -catechin gallate is a microcomponent of green tea Catechin, which can inhibit the activities of COX-1 and COX-2. It inhibits human Beta-Secretase, and chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum K1 have antiplasmodium activity.

Specifications

Synonyms
(?)-Catechin gallate | (-)-Catechin gallate | C22H18O10 | S00277 | (-)-Catechin gallate(CG) | (2S, 3R)-2-(3, 4-Dihydroxyphenyl)-5, 7-dihydroxychroman-3-yl 3, 4, 5-trihydroxybenzoate | AC-34201 | ent-Catechin 3-O-gallate | Benzoic acid, 3, 4, 5-trihydroxy-, 2-(3,
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Antioxidant constituent of green tea. At μM concentrations, it inhibits VEGF-induced tyrosine phosphorylation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cance
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%(HPLC)
Names and Identifiers
Canonical SmilesC1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
IUPAC Name[(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
InChIKeyLSHVYAFMTMFKBA-CTNGQTDRSA-N
INCHI1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21+/m1/s1
Isomeric SMILES C1[C@H]([C@@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
WGK Germany 3
Molecular Weight 442.37
Reaxy-Rn 372029
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=372029&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids
SubclassFlavans
Intermediate Tree Nodes Flavan-3-ols - Catechins
Direct ParentCatechin gallates
Alternative Parents 3'-hydroxyflavonoids  4'-hydroxyflavonoids  5-hydroxyflavonoids  7-hydroxyflavonoids  Galloyl esters  p-Hydroxybenzoic acid alkyl esters  m-Hydroxybenzoic acid esters  1-benzopyrans  Pyrogallols and derivatives  Benzoyl derivatives  Catechols  Alkyl aryl ethers  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Carboxylic acid esters  Polyols  Monocarboxylic acids and derivatives  Oxacyclic compounds  Hydrocarbon derivatives  Organic oxides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Catechin gallate - 3'-hydroxyflavonoid - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Hydroxyflavonoid - Galloyl ester - Gallic acid or derivatives - P-hydroxybenzoic acid alkyl ester - M-hydroxybenzoic acid ester - P-hydroxybenzoic acid ester - Benzoate ester - Chromane - Benzopyran - 1-benzopyran - Benzenetriol - Benzoic acid or derivatives - Pyrogallol derivative - Catechol - Benzoyl - Phenol - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Carboxylic acid ester - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Ether - Oxacycle - Organoheterocyclic compound - Polyol - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as catechin gallates. These are organic compounds containing a gallate moiety glycosidically linked to a catechin.
External Descriptors Flavans, Flavanols and Leucoanthocyanidins
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
PSMB5 Tclin Proteasome subunit beta type-5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FASN Tchem Fatty acid synthase (3390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGD Tchem 6-phosphogluconate dehydrogenase (58 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DYRK1A Tchem Dual-specificity tyrosine-phosphorylation regulated kinase 1A (6484 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fabG 3-oxoacyl-acyl-carrier protein reductase (70 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fabI Enoyl-acyl-carrier protein reductase (415 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
D1811124Certificate of AnalysisJul 09, 2025 C131962
D1811123Certificate of AnalysisJul 09, 2025 C131962
F23251338Certificate of AnalysisMay 15, 2025 C131962
F23251310Certificate of AnalysisApr 07, 2025 C131962
F23251322Certificate of AnalysisApr 07, 2025 C131962
F23251328Certificate of AnalysisApr 07, 2025 C131962
K2120606Certificate of AnalysisSep 18, 2023 C131962
K2120354Certificate of AnalysisSep 18, 2023 C131962
K2120360Certificate of AnalysisSep 18, 2023 C131962
F23251210Certificate of AnalysisMay 31, 2023 C131962
Chemical and Physical Properties
SolubilityDMSO : 100 mg/mL (226.06 mM)
Molecular Weight442.400 g/mol
XLogP31.500
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass442.09 Da
Monoisotopic Mass442.09 Da
Topological Polar Surface Area177.000 Ų
Heavy Atom Count32
Formal Charge0
Complexity649.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Yating Guo, Yili Shen, Boya Hu, Huichun Ye, Haowei Guo, Qiang Chu, Ping Chen.  (2023)  Decoding the Chemical Signatures and Sensory Profiles of Enshi Yulu: Insights from Diverse Tea Cultivars.  Plants-Basel,  12  (21): (3707).  [PMID:37960063] [10.3390/plants12213707]
2. Su Zhou, Jiaying Yang, Yani Pan, Xinyu Feng, Hao Hu, Shicheng Ma, Cansong Ou, Fangyuan Fan, Shuying Gong, Yuefei Wang, Ping Chen, Qiang Chu.  (2023)  Pu’ er raw tea extract alleviates DSS-induced colitis in mice by restoring intestinal barrier function and maintaining gut microbiota homeostasis.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2023.102750]
3. Wanglong Zhang, Yu Dai, Fan Xia, Xiaojin Zhang.  (2022)  Interfacial Molecular Lock: A Universal Strategy for Hydrogel Adhesion.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.2c01990]
4. Yu-Meng Zhu, Jun-Jie Dong, Jing Jin, Jin-Hua Liu, Xin-Qiang Zheng, Jian-Liang Lu, Yue-Rong Liang, Jian-Hui Ye.  (2021)  Roasting process shaping the chemical profile of roasted green tea and the association with aroma features.  FOOD CHEMISTRY,      [PMID:33714119] [10.1016/j.foodchem.2021.129428]
5. Dandan Qin, Qiushuang Wang, Hongjian Li, Xiaohui Jiang, Kaixing Fang, Qing Wang, Bo Li, Chendong Pan, Hualing Wu.  (2020)  Identification of key metabolites based on non-targeted metabolomics and chemometrics analyses provides insights into bitterness in Kucha [Camellia kucha (Chang et Wang) Chang].  FOOD RESEARCH INTERNATIONAL,      [PMID:33288175] [10.1016/j.foodres.2020.109789]
6. Meng Shi, Ying Nie, Xin-Qiang Zheng, Jian-Liang Lu, Yue-Rong Liang, Jian-Hui Ye.  (2016)  Ultraviolet B (UVB) Photosensitivities of Tea Catechins and the Relevant Chemical Conversions.  MOLECULES,  21  (10): (1345).  [PMID:27735869] [10.3390/molecules21101345]
7. Fang-Yuan Fan, Meng Shi, Ying Nie, Yue Zhao, Jian-Hui Ye, Yue-Rong Liang.  (2015)  Differential behaviors of tea catechins under thermal processing: Formation of non-enzymatic oligomers.  FOOD CHEMISTRY,      [PMID:26593500] [10.1016/j.foodchem.2015.09.056]
8. Yueming Liang, Zhusheng Liu, Yuelan Pang, Min Li, Shengmeng Zheng, Fujing Pan, Chunyu Guo, Qianhua Wu, Ting Chen, Qiang Li, Zhonghua Liu.  (2024)  Effects of storage durations on flavour and bacterial communities in Liupao tea.  FOOD CHEMISTRY,      [PMID:39756084] [10.1016/j.foodchem.2024.142697]
9. Yan Hu, Wei Chen, Mostafa Gouda, Huan Yao, Xinxin Zuo, Huahao Yu, Yuying Zhang, Lejia Ding, Fengle Zhu, Yuefei Wang, Xiaoli Li, Jihong Zhou, Yong He.  (2024)  Fungal fermentation of Fuzhuan brick tea: A comprehensive evaluation of sensory properties using chemometrics, visible near-infrared spectroscopy, and electronic nose.  FOOD RESEARCH INTERNATIONAL,      [PMID:38729704] [10.1016/j.foodres.2024.114401]
10. Huan Fang, Tong Wang, Lan Chen, Xiao-Zhi Wang, Hai-Long Wu, Yao Chen, Ru-Qin Yu.  (2024)  Rapid authenticity identification of high-quality Wuyi Rock tea by multidimensional fluorescence spectroscopy coupled with chemometrics.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2024.106632]
11. Yating Guo, Yani Pan, Xinyu Feng, Haowei Guo, Liping Liu, Kexin Zhang, Haojun Xie, Binkai Zhu, Shuying Gong, Qiang Chu, Hua Fang, Ping Chen.  (2025)  Reshaped local microbiology metabolism by raw tea according to pile fermentation in the dark tea.  Journal of Advanced Research,      [PMID:40064439] [10.1016/j.jare.2025.02.039]
12. Haozhen Li, Shuyao Wang, Xiaohua Zhang, Kangkang Song, Long Yang.  (2025)  Revealing novel insights into the improvement of greenhouse tea quality through exogenous substance interventions using targeted and untargeted metabolomics and microbial community analyses.  Food Chemistry-X,      [PMID:40213339] [10.1016/j.fochx.2025.102410]
13. Lan Zhang, Haocun Kong, Bimal Chitrakar, Xiaofeng Ban, Zhengbiao Gu, Yan Hong, Li Cheng, Zhaofeng Li, Caiming Li.  (2024)  The substitution sites of hydroxyl and galloyl groups determine the inhibitory activity of human pancreatic α-amylase in twelve tea polyphenol monomers.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38181909] [10.1016/j.ijbiomac.2023.129189]
14. Shiyu Zhang, Xinzhuan Yao, Yanxia Wang, Muhammad Safiullah Virk, Shiyu Tian, Zhenkedai Yuan, Qihong Zou, Linlin Li, Shenyuan Ye, Hu Tang, Litang Lu.  (2026)  Chemical and Sensory Characteristics of Baiye No.1 (BY1H) Yellow Tea: Insights into Flavoring Mechanism and Quality Valuation.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2026.108380]
15. Xiao-Lan Yu, Xizhe Zhu, Xinxin Lv, Jingming Ning, Haibo Yuan.  (2026)  Antagonistic Polyphenol Interactions Underlie the α-Glucosidase Inhibitory Activity of Keemun Black Tea.  Foods,  15  (6):   [PMID:] [10.3390/foods15061061]
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