FR 167653 - Moligand™, ≥99% , CAS No.158876-66-5

CAS: 158876-66-5 Cat. No.: F649945 Molecular Weight: 525.51 PubChem CID: 135484078

GRADE & PURITY Moligand™, ≥99%

Synonyms

FR 167653 sulfate | 1-(7-(4-Fluorophenyl)-8-(pyridin-4-yl)-3,4-dihydropyrazolo[5,1-c][1,2,4]triazin-2(1H)-yl)-2-phenylethane-1,2-dione sulfate

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo

In Vivo

FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Inbred male Balbuc mice (aged 8 weeks) Dosage: 32 kg/mg Administration: Subcutaneous injection; 24-48 hours Result: The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.

Form:Solid

Specifications

Synonyms

FR 167653 sulfate | 1-(7-(4-Fluorophenyl)-8-(pyridin-4-yl)-3, 4-dihydropyrazolo[5, 1-c][1, 2, 4]triazin-2(1H)-yl)-2-phenylethane-1, 2-dione sulfate

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relie

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Isomeric SMILES: C1CN(NC2=C(C(=NN21)C3=CC=C(C=C3)F)C4=CC=NC=C4)C(=O)C(=O)C5=CC=CC=C5.OS(=O)(=O)O
• PubChem CID: 135484078
• Molecular Weight: 525.51

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (190.29 mM; Need ultrasonic)
• Molecular Weight: 525.500 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 4
• Exact Mass: 525.112 Da
• Monoisotopic Mass: 525.112 Da
• Topological Polar Surface Area: 163.000 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 755.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3