I-BET 151 dihydrochloride - ≥98%(HPLC) , CAS No.1883545-47-8

CAS: 1883545-47-8 Cat. No.: I287715 Molecular Weight: 488.37 PubChem CID: 121513850

GRADE & PURITY ≥98%(HPLC)

Synonyms

I-BET151 dihydrochloride | GSK1210151A dihydrochloride | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

I-BET151 dihydrochloride | GSK1210151A dihydrochloride | 7-(3, 5-Dimethyl-4-isoxazolyl)-1, 3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4, 5-c]quinolin-2-one dihydrochloride

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1cell cycle arrest in MLL-fusion leukemic cell linesin vitro(IC50values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively);

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 488202689
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202689
• Canonical Smiles: CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)C(C)C5=CC=CC=N5)OC.Cl.Cl
• IUPAC Name: 7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one;dihydrochloride
• InChIKey: UFLKDZBLUNJNJS-FFXKMJQXSA-N
• INCHI: 1S/C23H21N5O3.2ClH/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17;;/h5-11,13H,1-4H3,(H,26,29);2*1H/t13-;;/m1../s1
• PubChem CID: 121513850
• Molecular Weight: 488.37

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 41.54, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 41.54, Max Conc. mM: 100; Solvent:water, Max Conc. mg/mL: 48.84, Max Conc. mM: 100