GRADE & PURITY 10mM in DMSO

Synonyms

endo-IWR 1 | Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

IWR-1-endo IWR-1-endo (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
In vitro

Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.

In vivo

Cell Data

cell lines：HCT116, A2780, and U2OS cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

endo-IWR 1 | Benzamide, 4-[(3aR, 4S, 7R, 7aS)-1, 3, 3a, 4, 7, 7a-hexahydro-1, 3-dioxo-4, 7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

IWR-1-endo (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6
• Molecular Weight: 409.44
• Reaxy-Rn: 30206857
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30206857&ln=

Associated Targets(Human)

TNKS Tchem Tankyrase-1 (3 Activities)

Discover Target: TNKS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNKS2 Tchem Tankyrase-2 (6 Activities)

Discover Target: TNKS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Chen Min, Huang Shanjiao, Weng Shuoyun, Weng Junting, Guo Rongjie, Shi Bingbing, Liu Danjuan.  (2023)  Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:38133657] [10.1007/s00210-023-02897-5]