L-N6-(1-Iminoethyl)lysine dihydrochloride - ≥95% , CAS No.159190-45-1

CAS: 159190-45-1 Cat. No.: S167638 Molecular Weight: 260.16 EC Number: 803-059-8 PubChem CID: 2733505

GRADE & PURITY ≥95%

Synonyms

L-N6-(1-Iminoethyl)lysine dihydrochloride | AKOS027320886 | L-N(6)-(1-iminoethyl)lysine dihydrochloride | L-NIL (dihydrochloride) | N(6)-acetimidoyl-L-lysine dihydrochloride | L-Lysine, N6-(1-iminoethyl)-, dihydrochloride | N(6)-acetimidoyl-L-lysine hydro

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

application：

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:

to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine

to study its effects on leptin-induced inflammation in hepatocytes

to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

product description：

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS

Specifications

Synonyms

L-N6-(1-Iminoethyl)lysine dihydrochloride | AKOS027320886 | L-N(6)-(1-iminoethyl)lysine dihydrochloride | L-NIL (dihydrochloride) | N(6)-acetimidoyl-L-lysine dihydrochloride | L-Lysine, N6-(1-iminoethyl)-, dihydrochloride | N(6)-acetimidoyl-L-lysine hydro

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Selective inhibitor of inducible nitric oxide synthase (iNOS).

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC(=NCCCCC(C(=O)O)N)N.Cl.Cl
• IUPAC Name: (2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;dihydrochloride
• InChIKey: OQIBCXRAFAHXMM-KLXURFKVSA-N
• INCHI: 1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
• Isomeric SMILES: CC(=NCCCC[C@@H](C(=O)O)N)N.Cl.Cl
• WGK Germany: 3
• PubChem CID: 2733505
• Molecular Weight: 260.16

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Medium-chain fatty acids Amino acids Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Carboximidamides Carboxamidines Organopnictogen compounds Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - Medium-chain fatty acid - Fatty acid - Fatty acyl - Amino acid - Amidine - Carboxylic acid amidine - Carboxylic acid - Monocarboxylic acid or derivatives - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Carbonyl group - Amine - Primary aliphatic amine - Organic oxygen compound - Organopnictogen compound - Hydrochloride - Organic oxide - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)

Discover Target: NOS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)

Discover Target: Nos2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: water: 50 mg/mL, clear, colorless
• Sensitivity: Hygroscopic
• Molecular Weight: 260.160 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 259.085 Da
• Monoisotopic Mass: 259.085 Da
• Topological Polar Surface Area: 102.000 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 192.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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