SphK

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  1. N,N-Dimethyl-D-erythro-sphingosine (PKC inhibitor)
    CAS: 119567-63-4 Fórmula: C20H41NO2 Peso molecular: 327.5
    ◐ .Sob encomenda · 8–12 semanas Item #: N274922
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    Identificadores técnicos
    Nome IUPAC
    (E,2S,3R)-2-(dimethylamino)octadec-4-ene-1,3-diol
    SMILES
    CCCCCCCCCCCCCC=CC(C(CO)N(C)C)O
    InChIKey
    YRXOQXUDKDCXME-YIVRLKKSSA-N
    InChI
    1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
    Sinónimos
    SR-01000946568-1 | CHEBI:78759 | N,N-Dimethyl-D-erythrosphingenine | NCGC00161359-01 | BSPBio_001420 | (2S,3R,4E)-2-(...
  2. SLM 6031434 hydrochloride
    CAS: 1897379-34-8 PubChem CID: 134812833 Fórmula: C₂₂H₃₀F₃N₅O₂.HCl Peso molecular: 489.96
    ◐ .Sob encomenda · 8–12 semanas Item #: S288509
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    Nome IUPAC
    (2S)-2-[3-[4-octoxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochloride
    SMILES
    CCCCCCCCOC1=C(C=C(C=C1)C2=NOC(=N2)C3CCCN3C(=N)N)C(F)(F)F.Cl
    InChIKey
    YIGAQKBPLMSWOD-LMOVPXPDSA-N
    InChI
    1S/C22H30F3N5O2.ClH/c1-2-3-4-5-6-7-13-31-18-11-10-15(14-16(18)22(23,24)25)19-28-20(32-29-19)17-9-8-12-30(17)21(26)27;/h10-11,14,17H,2-9,12-13H2,1H3,(Hshow more
    Sinónimos
    (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
  3. MP A08, Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
    CAS: 219832-49-2 Fórmula: C27H25N3O4S2 Peso molecular: 519.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: M288047
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    Nome IUPAC
    4-methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide
    SMILES
    CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C=NC3=CC=CC=C3NS(=O)(=O)C4=CC=C(C=C4)C
    InChIKey
    FLDBNMYJUMAXDQ-UHFFFAOYSA-N
    InChI
    1S/C27H25N3O4S2/c1-20-11-15-23(16-12-20)35(31,32)29-25-8-4-3-7-22(25)19-28-26-9-5-6-10-27(26)30-36(33,34)24-17-13-21(2)14-18-24/h3-19,29-30H,1-2H3
    Sinónimos
    NSC 122314 | 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide | MP-A08
  4. PF 543 hydrochloride
    CAS: 1706522-79-3 PubChem CID: 121230770 Fórmula: C27H31NO4S•HCl Peso molecular: 502.07
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: P286792
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    Nome IUPAC
    [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol;hydrochloride
    SMILES
    CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4.Cl
    InChIKey
    WNKWAZFYPZMDGJ-VQIWEWKSSA-N
    InChI
    1S/C27H31NO4S.ClH/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;/h2-4,7-12,14-16,25,29H,5-6,1show more
    Sinónimos
    (2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2- pyrrolidinemethanol hydrochloride
  5. PF-543, Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
    CAS: 1415562-82-1 Fórmula: C27H31NO4S Peso molecular: 465.6
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: P125702
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    Nome IUPAC
    [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol
    SMILES
    CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4
    InChIKey
    NPUXORBZRBIOMQ-RUZDIDTESA-N
    InChI
    1S/C27H31NO4S/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29/h2-4,7-12,14-16,25,29H,5-6,13,17-show more
    Sinónimos
    DTXSID3063386 | BDBM50041978 | (2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrol...
  6. ABC294640, Sphingosine kinase 2 inhibitor
    CAS: 915385-81-8 Fórmula: C23H25ClN2O Peso molecular: 380.91
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: A127517
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    Identificadores técnicos
    Nome IUPAC
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
    SMILES
    C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl
    InChIKey
    CAOTVXGYTWCKQE-UHFFFAOYSA-N
    InChI
    1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
    Sinónimos
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide | ABC294640 | ABC-294640 | BA162479 | BDBM50393642 ...
  7. SKI II, Inhibitor of delta 4-desaturase; sphingolipid 1;Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
    CAS: 312636-16-1 PubChem CID: 753704 Fórmula: C15H11ClN2OS Peso molecular: 302.78
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: S129855
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    Identificadores técnicos
    Nome IUPAC
    4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
    SMILES
    C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
    InChIKey
    ZFGXZJKLOFCECI-UHFFFAOYSA-N
    InChI
    1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
    Sinónimos
    CCG-265019 | HMS3413G03 | SKI II | Ski ii (sphk-i2) | HMS3650M12 | NCGC00092309-01 | SKI 2 | BDBM50312869 | HMS3677G0...
  8. SKI-I
    CAS: 306301-68-8 PubChem CID: 137269090 Fórmula: C25H18N4O2 Peso molecular: 406.44
    ◐ .Sob encomenda · 8–12 semanas Item #: S275155
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    Identificadores técnicos
    Nome IUPAC
    N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-5-naphthalen-2-ylpyrazolidine-3-carboxamide
    SMILES
    C1C(NNC1C(=O)NN=CC2=C(C=CC3=CC=CC=C32)O)C4=CC5=CC=CC=C5C=C4
    InChIKey
    LMCALHGHWCFFHD-CVKSISIWSA-N
    InChI
    1S/C25H22N4O2/c30-24-12-11-17-6-3-4-8-20(17)21(24)15-26-29-25(31)23-14-22(27-28-23)19-10-9-16-5-1-2-7-18(16)13-19/h1-13,15,22-23,27-28,30H,14H2,(H,29,show more
    Sinónimos
    5-(2-Naphthalenyl)-1H-pyrazole-3-carboxylicacid2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
  9. omega-biotinyl D-erythro-sphingosine
    CAS: 752987-57-8 PubChem CID: 46891739 Fórmula: C28H52N4O4S Peso molecular: 540.802
    ◐ .Sob encomenda · 8–12 semanas Item #: O130651
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    Nome IUPAC
    5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[(E,16R,17S)-17-amino-16,18-dihydroxyoctadec-14-enyl]pentanamide
    SMILES
    C1C2C(C(S1)CCCCC(=O)NCCCCCCCCCCCCCC=CC(C(CO)N)O)NC(=O)N2
    InChIKey
    NYQVYZZGZCNEMF-RPRIXWAOSA-N
    InChI
    1S/C28H52N4O4S/c29-22(20-33)24(34)16-12-10-8-6-4-2-1-3-5-7-9-11-15-19-30-26(35)18-14-13-17-25-27-23(21-37-25)31-28(36)32-27/h12,16,22-25,27,33-34H,1-1show more
  10. ABC294640, Sphingosine kinase 2 inhibitor
    CAS: 915385-81-8 Fórmula: C23H25ClN2O Peso molecular: 380.91
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: A426910
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    Preços e tamanhos do pacote
    Identificadores técnicos
    Nome IUPAC
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
    SMILES
    C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl
    InChIKey
    CAOTVXGYTWCKQE-UHFFFAOYSA-N
    InChI
    1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
    Sinónimos
    3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide | ABC294640 | ABC-294640 | BA162479 | BDBM50393642 ...
  11. CAY10621 (SKI 5C)
    CAS: 120005-55-2 Fórmula: C26H45NO4 Peso molecular: 435.65
    ◐ .Sob encomenda · 8–12 semanas Item #: C276256
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    Nome IUPAC
    tert-butyl (4S)-4-hexadec-2-ynoyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
    SMILES
    CCCCCCCCCCCCCC#CC(=O)C1COC(N1C(=O)OC(C)(C)C)(C)C
    InChIKey
    YGBSGZPIDCXNEH-QFIPXVFZSA-N
    InChI
    1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1
    Sinónimos
    tert-Butyl(4S)-4-hexadec-2-ynoyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
  12. Defensamide (MHP)
    CAS: 1104874-94-3 Fórmula: C16H23NO4   Peso molecular: 293.36
    10mM in DMSO
    ● Em estoque — Armazém nos EUA, envio para a EU* Item #: D420603
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    Preços e tamanhos do pacote
    Identificadores técnicos
    Nome IUPAC
    methyl (2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoate
    SMILES
    CCCCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)OC
    InChIKey
    GBTVWZMJUZJPBU-AWEZNQCLSA-N
    InChI
    1S/C16H23NO4/c1-3-4-5-6-15(19)17-14(16(20)21-2)11-12-7-9-13(18)10-8-12/h7-10,14,18H,3-6,11H2,1-2H3,(H,17,19)/t14-/m0/s1
    Sinónimos
    ZB1539 | (S)-Methyl 2-(hexanamido)-3-(4-hydroxyphenyl)propanoate | (S)-methyl 2-hexanamido-3-(4-hydroxyphenyl)propano...
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Perguntas frequentes

What can I find under SphK?
This listing collects compounds associated with SphK within our Immunology/Inflammation area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for SphK?
Consider the reported potency of each SphK compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for SphK compounds?
Each SphK product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search SphK compounds by activity or structure?
Yes. Filter the SphK listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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