Hedgehog

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  1. GSA10, Allosteric modulator of SMO
    CAS: 300833-95-8 EC Number: 808-811-9 Formula: C26H30N2O5 Molecular Weight: 450.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    ◐ .Made to order · 8–12 wks Item #: G275761
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    IUPAC Name
    propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate
    SMILES
    CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O
    InChIKey
    MDLUYYGRCGDKGL-UHFFFAOYSA-N
    InChI
    1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(show more
    Synonyms
    AS-16537 | AKOS000624567 | GTPL10326 | GSA 10; GSA-10 | J-017772 | STK034810 | 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quino...
  2. Robotnikinin
    CAS: 1132653-79-2 PubChem CID: 25109985 Formula: C25H27ClN2O4 Molecular Weight: 454.95
    ● In Stock — US Item #: R346308
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    IUPAC Name
    N-[(4-chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
    SMILES
    C1CC(=O)OC(CNC(=O)C(CC=C1)CC(=O)NCC2=CC=C(C=C2)Cl)C3=CC=CC=C3
    InChIKey
    DRDSZZCLAHXSAE-BQIDRLATSA-N
    InChI
    1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,show more
    Synonyms
    N-(4-chlorobenzyl)-2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetamide | N-[(4-chlorophenyl)me...
  3. 1-Methyladenosine
    CAS: 15763-06-1 Formula: C11H15N5O4 Molecular Weight: 281.27
    Solid ≥98%
    ● In Stock — US Item #: M303015
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    IUPAC Name
    (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methylpurin-9-yl)oxolane-3,4-diol
    SMILES
    CN1C=NC2=C(C1=N)N=CN2C3C(C(C(O3)CO)O)O
    InChIKey
    GFYLSDSUCHVORB-IOSLPCCCSA-N
    InChI
    1S/C11H15N5O4/c1-15-3-14-10-6(9(15)12)13-4-16(10)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11-12,17-19H,2H2,1H3/t5-,7-,8-,11-/m1/s1
    Synonyms
    H10051 | AC-32347 | Adenosine, N,6-didehydro-1,9-dihydro-1-methyl- | HY-113081 | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6...
  4. Neurodazine
    CAS: 937807-66-4 Formula: C27H21ClN2O3 Molecular Weight: 456.93
    ◐ .Made to order · 8–12 wks Item #: N275013
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    IUPAC Name
    2-[5-(3-chlorophenyl)furan-2-yl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
    SMILES
    COC1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(O3)C4=CC(=CC=C4)Cl)C5=CC=C(C=C5)OC
    InChIKey
    FEEOFPAEDSMOTO-UHFFFAOYSA-N
    InChI
    1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)
    Synonyms
    Neurodazine - CAS 937807-66-4 | Q27166384 | BRD-K22631935-001-01-9 | CHEBI:94546 | NCGC00344091-03 | 2-[5-(3-Chloro-p...
  5. SMANT hydrochloride
    CAS: 1177600-74-6 PubChem CID: 2900213 Formula: C16H24BrClN2O Molecular Weight: 375.73
    ● In Stock — US Item #: S288275
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    IUPAC Name
    N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide;hydrochloride
    SMILES
    CC1CC(CN(C1)CCC(=O)NC2=CC=C(C=C2)Br)C.Cl
    InChIKey
    XQESCHFXROUCOQ-UHFFFAOYSA-N
    InChI
    1S/C16H23BrN2O.ClH/c1-12-9-13(2)11-19(10-12)8-7-16(20)18-15-5-3-14(17)4-6-15;/h3-6,12-13H,7-11H2,1-2H3,(H,18,20);1H
    Synonyms
    N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride | N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-y...
  6. Itraconazole-d5 (major)
    CAS: 1217510-38-7 Formula: C35H33D5Cl2N8O4 Molecular Weight: 710.66
    ◐ .Made to order · 8–12 wks Item #: I343299
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    IUPAC Name
    4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3,3,4,4,4-pentadeushow more
    SMILES
    CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
    InChIKey
    VHVPQPYKVGDNFY-VXTATNQMSA-N
    InChI
    1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43show more
    Synonyms
    HY-17514S | Itraconazole-d5 (major) | 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-di...
  7. JK184
    CAS: 315703-52-7 Formula: C19H18N4OS Molecular Weight: 350.44
    ● In Stock — US Item #: J169510
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    IUPAC Name
    N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
    SMILES
    CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
    InChIKey
    ROYXIPOUVGDTAO-UHFFFAOYSA-N
    InChI
    1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
    Synonyms
    AKOS016003923 | DTXSID70360042 | B2693-462944 | BDBM50249523 | N-(4-ETHOXYPHENYL)-4-{2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-...
  8. Jervine
    CAS: 469-59-0 EC Number: 207-417-9 Formula: C27H39NO3 Molecular Weight: 425.6
    ● In Stock — US Item #: J135916
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    Technical Identifiers
    IUPAC Name
    (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethylspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,show more
    SMILES
    CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1
    InChIKey
    CLEXYFLHGFJONT-DNMILWOZSA-N
    InChI
    1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2show more
    Synonyms
    NSC7520 | NSC-7520 | CCG-208226 | Spiro[9H-benzo[a]fluorene-9,2-b]-pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7...
  9. Vismodegib (GDC-0449), Smoothened homolog inhibitor
    CAS: 879085-55-9 EC Number: 806-752-3 PubChem CID: 24776445 Formula: C19H14Cl2N2O3S Molecular Weight: 421.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: V127477
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    IUPAC Name
    2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide
    SMILES
    CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
    InChIKey
    BPQMGSKTAYIVFO-UHFFFAOYSA-N
    InChI
    1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
    Synonyms
    Vismodegib (USAN/INN) | 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)benzamide | 2-chloro-N-(4-chl...
  10. Cyclopamine, Antagonist of SMO
    CAS: 4449-51-8 EC Number: 628-058-8 Formula: C27H41NO2 Molecular Weight: 411.62
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In Stock — US Item #: C125994
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    Technical Identifiers
    IUPAC Name
    (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-heshow more
    SMILES
    CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
    InChIKey
    QASFUMOKHFSJGL-LAFRSMQTSA-N
    InChI
    1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-show more
    Synonyms
    (3beta,22S,23R)-17,23-epoxyveratraman-3-ol | A881419 | HMS3403D13 | GAMMA CYCLODEXTRIN [MART.] | BRD-K58938839-001-03...
  11. SANT-1, Antagonist of SMO
    CAS: 304909-07-7 Formula: C23H27N5 Molecular Weight: 373.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In Stock — US Item #: S129830
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    Technical Identifiers
    IUPAC Name
    (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
    SMILES
    CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4
    InChIKey
    FOORCIAZMIWALX-JJIBRWJFSA-N
    InChI
    1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
    Synonyms
    EX-A1250 | HMS3412P14 | NCGC00092291-01 | QUIRAL TADEODAL | SANT-1 | SCHEMBL10063651 | (E)-4-Benzyl-N-((3,5-dimethyl-...
  12. SANT-2, Antagonist of SMO
    CAS: 329196-48-7 PubChem CID: 1367095 Formula: C26H26ClN3O4 Molecular Weight: 479.96
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In Stock — US Item #: S275667
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    IUPAC Name
    N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
    SMILES
    CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3
    InChIKey
    VQOJFGFKIVFMDH-UHFFFAOYSA-N
    InChI
    1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)show more
    Synonyms
    GTPL10331 | J-018936 | HY-107408 | SR-01000419345 | NCGC00263210-04 | BDBM50249489 | HMS3414C13 | NCGC00263210-06 | S...
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Frequently Asked Questions

What can I find under Hedgehog?
This listing collects compounds associated with Hedgehog within our Stem Cell/Wnt area — inhibitors, agonists or antagonists, and reference tool compounds. Each entry links to its structure, CAS number, and reported activity so you can confirm the annotation before ordering.
What should I consider when picking a compound for Hedgehog?
Consider the reported potency of each Hedgehog compound and the assay behind it, selectivity against closely related targets, cell permeability if you are working in cells, and stability in your buffer. Two chemically distinct compounds giving the same phenotype is much stronger evidence than one.
What quality information is provided for Hedgehog compounds?
Each Hedgehog product page lists purity, identity data, molecular formula and weight, and storage conditions, with a lot-specific Certificate of Analysis available. Solubility and handling notes are on the datasheet. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
Can I search Hedgehog compounds by activity or structure?
Yes. Filter the Hedgehog listing by mechanism — inhibitor, agonist, antagonist — and search by target name or gene symbol, CAS number, molecular formula, or SMILES to reach exact structures and close analogs. For bulk quantities or items not listed, contact [email protected].

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