MeOSuc-AAPV-pNA, Chromogenic Substrate, CAS No.70967-90-7

CAS: 70967-90-7 Cat. No.: M331874 Molecular Weight: 590.63 Beilstein Registry Number: 6266359

GRADE & PURITY Moligand™, ≥98%

Overview

MeOSuc-AAPV-pNA, Chromogenic Substrate is a sensitive chromogenic substrate for PR3 (proteinase 3; PRTN3) and neutrophil elastase. PR3 is a polymorphonuclear leukocyte (PMNL) serine proteinase that degrades a variety of matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV and contributes to the proteolytic generation of antimicrobial peptides. Neutrophil elastase is a serine proteinase that during inflammation, is secreted by neutrophils to destroy bacteria as well as host tissue. Evaluating human and murine PR3 and neutrophil elastase enzymes are helpful to understanding PR3-related and inflammatory autoimmune processes. Researchers have used this product in cystic fibrosis research, as elastin degradation has been reported to increase in cystic fibrosis patients. Hydrolysis or cleavage of this substrate product can be detected at 405-410 nm. This product is not a suitable substrate for cathepsin G nor chymotrypsin.

Specifications

Product Name

MeOSuc-AAPV-pNA, Chromogenic Substrate, CAS No.70967-90-7

Synonyms

MeOSuc-Ala-Ala-Pro-Val-PNA | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide

Grade

Moligand™

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elasta.

Sequence

N-Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide

CAS

70967-90-7

Molecule Type

Small molecule

Storage and Shipping

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Valine and derivatives N-acyl-alpha amino acids and derivatives Proline and derivatives Alpha amino acid amides Alanine and derivatives Nitrobenzenes Anilides Nitroaromatic compounds N-arylamides N-acylpyrrolidines Pyrrolidinecarboxamides Fatty acid methyl esters N-acyl amines Tertiary carboxylic acid amides Methyl esters Secondary carboxylic acid amides Organic oxoazanium compounds Azacyclic compounds Monocarboxylic acids and derivatives Propargyl-type 1,3-dipolar organic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organic salts Organic zwitterions
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-oligopeptide - N-acyl-alpha amino acid or derivatives - Valine or derivatives - Proline or derivatives - Alpha-amino acid amide - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Nitrobenzene - Anilide - N-acylpyrrolidine - N-arylamide - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Nitroaromatic compound - Fatty acid methyl ester - Fatty acid ester - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Fatty acyl - Benzenoid - Methyl ester - Tertiary carboxylic acid amide - Pyrrolidine - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid ester - Organic nitro compound - C-nitro compound - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Azacycle - Organic oxoazanium - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic zwitterion - Organic oxide - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organic salt - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y