Naminidil - ≥99% , Sulfonylurea receptors; K-ATP channels opener, CAS No.220641-11-2, Sulfonylurea receptors; K-ATP channels opener

CAS: 220641-11-2 Cat. No.: N646738 Molecular Weight: 269.34 PubChem CID: 158438

GRADE & PURITY ≥99%

Synonyms

1-cyano-3-(4-cyanophenyl)-2-[(2R)-3,3-dimethylbutan-2-yl]guanidine | Naminidil | Naminidil [USAN:INN] | NAMINIDIL [USAN] | NAMINIDIL [INN] | AKOS040742268 | 7K50VT05OD | MS-23810 | Naminidil, (r)- | BMS-234303-01 | HY-100276 | Q27268440 | Guanidine, N-cya

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Naminidil is a cyanoguanidine K ATP opener.

In Vitro

Naminidil works through the potassium (K) channel. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Potassium Channel

Specifications

Synonyms

1-cyano-3-(4-cyanophenyl)-2-[(2R)-3, 3-dimethylbutan-2-yl]guanidine | Naminidil | Naminidil [USAN:INN] | NAMINIDIL [USAN] | NAMINIDIL [INN] | AKOS040742268 | 7K50VT05OD | MS-23810 | Naminidil, (r)- | BMS-234303-01 | HY-100276 | Q27268440 | Guanidine, N-cya

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Naminidil is a cyanoguanidine K ATP opener.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

OPENER

Mechanism of action

Sulfonylurea receptors; K-ATP channels opener

Purity

≥99%

Product Properties

• ALogP: 3.5

Names and Identifiers

• Pubchem Sid: 528766366
• Canonical Smiles: CC(C(C)(C)C)N=C(NC#N)NC1=CC=C(C=C1)C#N
• IUPAC Name: 1-cyano-3-(4-cyanophenyl)-2-[(2R)-3,3-dimethylbutan-2-yl]guanidine
• InChIKey: PGYDRGZVXVVZQC-LLVKDONJSA-N
• INCHI: 1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)/t11-/m1/s1
• Isomeric SMILES: C[C@H](C(C)(C)C)N=C(NC#N)NC1=CC=C(C=C1)C#N
• Alternate CAS: 220641-11-2
• PubChem CID: 158438
• Molecular Weight: 269.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzonitriles

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzonitriles
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzonitriles
• Alternative Parents: Guanidines Propargyl-type 1,3-dipolar organic compounds Nitriles Carboximidamides Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzonitrile - Guanidine - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Nitrile - Carbonitrile - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzonitriles. These are organic compounds containing a benzene bearing a nitrile substituent.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (464.10 mM; Need ultrasonic)
• Molecular Weight: 269.340 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 269.164 Da
• Monoisotopic Mass: 269.164 Da
• Topological Polar Surface Area: 84.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 434.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1