PKI 166 hydrochloride - ≥98%(HPLC) , CAS No.2230253-82-2

CAS: 2230253-82-2 Cat. No.: P287660 Molecular Weight: 366.84 PubChem CID: 91691117

GRADE & PURITY ≥98%(HPLC)

Synonyms

4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol hydrochloride

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2, 3-d]pyrimidin-6-yl]phenol hydrochloride

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

PKI 166 hydrochloride is a potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bi

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: CC(C1=CC=CC=C1)NC2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)O.Cl
• IUPAC Name: 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol;hydrochloride
• InChIKey: ZPTWAAIZEGWMGX-BTQNPOSSSA-N
• INCHI: 1S/C20H18N4O.ClH/c1-13(14-5-3-2-4-6-14)23-19-17-11-18(24-20(17)22-12-21-19)15-7-9-16(25)10-8-15;/h2-13,25H,1H3,(H2,21,22,23,24);1H/t13-;/m1./s1
• Isomeric SMILES: C[C@H](C1=CC=CC=C1)NC2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)O.Cl
• PubChem CID: 91691117
• Molecular Weight: 366.84

Chemical and Physical Properties

• Solubility: DMSO(Maximum concentration 100 mM); Ethanol(Maximum concentration 50 mM)