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SC 51089 free base - ≥98% , CAS No.146033-03-6
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Protected from light,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Protected from light,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
SC 51089 free base is a selective antagonist of prostaglandin E 2 EP1 receptor , with K i s of 1.3, 11.2, 17.5, and 61.1 μM for EP1 , TP , EP3 , and FP receptors , respectively. SC 51089 free base exhibits neuroprotective activity
In Vitro
SC 51089 free base (5 μM; 24 h) attenuates prostaglandin E2 (PGE2)-induced the death of neuronal cells exposed to t-BuOOH. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SC 51089 free base (40 μg/kg; infused i.p. for 28 d) ameliorates motor coordination and balance dysfunction and rescues long-term memory deficit in R6/1 mouse model of HD. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of ageDosage: 40 μg/kg/day Administration: Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system Result: Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.
Form:Solid
IC50& Target:EP1 1.3 μM (Ki) TP 11.2 μM (Ki) EP3 17.5 μM (Ki) FP 61.1 μM (Ki)
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
SC 51089 free base is a selective antagonist of prostaglandin E 2 EP1 receptor , with K i s of 1.3, 11.2, 17.5, and 61.1 μM for EP1 , TP , EP3 , and FP receptors , respectively. SC 51089 free base exhibits neuroprotective activity.
Storage
Store at 2-8°C, Protected from light, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
| Molecular Weight | 422.86 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (236.48 mM; Need ultrasonic) |
|---|
Solution Calculators
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