SDZ 220-581 hydrochloride - 10mM in DMSO , CAS No.179411-93-9

CAS: 179411-93-9 Cat. No.: S655898 Molecular Weight: 406.2 EC Number: 808-496-8 PubChem CID: 78357772

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pK i value of 7.7

In Vivo

SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male OF-l mice (18-26 g) Dosage: 3.2 mg/kg, 10 mg/kg, 32 mg/kg Administration: Oral administration; for 24 hours Result: Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.

IC50& Target:pKi: 7.7 ( NMDA receptor )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pK i value of 7.7.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C(=C1)C2=CC(=CC(=C2)CP(=O)(O)O)C[C@@H](C(=O)O)N)Cl.Cl
• WGK Germany: 3
• PubChem CID: 78357772
• Molecular Weight: 406.2