Substance P Fragment 1-7 - ≥97%(HPLC) , CAS No.68060-49-1

CAS: 68060-49-1 Cat. No.: S118934 Molecular Weight: 900.04 PubChem CID: 3368303

GRADE & PURITY ≥97%(HPLC)

Synonyms

AS-58201 | Substance P (1-7) | AKOS037645190 | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH | FT-0688063 | DTXSID30391872 | PD087830 | Substance P 1-7 | 2-[[5-amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Amino Acid Sequence Arg-Pro-Lys-Pro-Gln-Gln-Phe

Specifications

Synonyms

AS-58201 | Substance P (1-7) | AKOS037645190 | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH | FT-0688063 | DTXSID30391872 | PD087830 | Substance P 1-7 | 2-[[5-amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]

Specifications & Purity

≥97%(HPLC)

Biochemical and Physiological Mechanisms

Fragment that gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.Truncated sensory neuropeptide. Involved in pain signal transmission. Modulates the function of inflammatory and immune responses. Act on tachykinin recep

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%(HPLC)

Names and Identifiers

• Canonical Smiles: C1CC(N(C1)C(=O)C(CCCN=C(N)N)N)C(=O)NC(CCCCN)C(=O)N2CCCC2C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)O
• IUPAC Name: 2-[[5-amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoic acid
• InChIKey: KPHDBQWTCKBKIL-UHFFFAOYSA-N
• INCHI: 1S/C41H65N13O10/c42-19-5-4-12-28(51-37(60)30-13-7-21-53(30)38(61)25(43)11-6-20-48-41(46)47)39(62)54-22-8-14-31(54)36(59)50-27(16-18-33(45)56)34(57)49-26(15-17-32(44)55)35(58)52-29(40(63)64)23-24-9-2-1-3-10-24/h1-3,9-10,25-31H,4-8,11-23,42-43H2,(H2,44,55)(H2,45,56)(H,49,57)(H,50,59)(H,51,60)(H,52,58)(H,63,64)(H4,46,47,48)
• Isomeric SMILES: C1CC(N(C1)C(=O)C(CCCN=C(N)N)N)C(=O)NC(CCCCN)C(=O)N2CCCC2C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)O
• PubChem CID: 3368303
• Molecular Weight: 900.04

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Phenylalanine and derivatives Glutamine and derivatives Proline and derivatives N-acyl-alpha amino acids Alpha amino acid amides Phenylpropanoic acids Amphetamines and derivatives Pyrrolidinecarboxamides N-acylpyrrolidines N-acyl amines Tertiary carboxylic acid amides Secondary carboxylic acid amides Amino acids Primary carboxylic acid amides Guanidines Azacyclic compounds Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Carboximidamides Monocarboxylic acids and derivatives Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-oligopeptide - Phenylalanine or derivatives - Glutamine or derivatives - Proline or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Alpha-amino acid amide - 3-phenylpropanoic-acid - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Fatty acyl - Monocyclic benzene moiety - N-acyl-amine - Fatty amide - Benzenoid - Pyrrolidine - Tertiary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Primary carboxylic acid amide - Secondary carboxylic acid amide - Guanidine - Amino acid - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Carboxylic acid - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Monocarboxylic acid or derivatives - Amine - Organic oxide - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Primary aliphatic amine - Primary amine - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Molecular Weight: 900.000 g/mol
• XLogP3: -6.100
• Hydrogen Bond Donor Count: 11
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 27
• Exact Mass: 899.498 Da
• Monoisotopic Mass: 899.498 Da
• Topological Polar Surface Area: 397.000 Ų
• Heavy Atom Count: 64
• Formal Charge: 0
• Complexity: 1670.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 7
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Guo Xiaoyang, Liu Jia, Jiang Lingdong, Gong Wanjun, Wu Huixia, He Qianjun.  (2021)  Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H2S therapy of cancer.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-14).  [PMID:34649589] [10.1186/s12951-021-01042-9]

2. Xuan Lu, Yang Hu, Jiazhuang Guo, Cai-Feng Wang, Su Chen.  (2019)  Fiber-Spinning-Chemistry Method toward In Situ Generation of Highly Stable Halide Perovskite Nanocrystals.  Advanced Science,  6  (22): (1901694).  [PMID:31763152] [10.1002/advs.201901694]

3. Weidong Zhou, Tao Xu, Xiaowei Wang, Erjuan Zhi, Jun Liu, Wei Zhang, Junhui Ji.  (2012)  In situ polymerized nanocomposites of poly(butylene succinate)/Tio2 nanofibers: molecular weight, morphology, and thermal properties.  JOURNAL OF APPLIED POLYMER SCIENCE,  127  (1): (733-739).  [PMID:] [10.1002/app.37724]