Terlipressin acetate - ≥99% , CAS No.1884420-36-3

CAS: 1884420-36-3 Cat. No.: T651556 Molecular Weight: 1347.48 PubChem CID: 72941948

GRADE & PURITY ≥99%

Synonyms

Q27251135 | 14636-12-5 , Terlipressin | GLXC-25927 | HY-12554A | Heamopressin | UNII-10B4G9161D | Terlipressin (acetate) | Terlipressin diacetate anhydrous | Terlipressin acetate anhydrous | 10B4G9161D | Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-Nh2

Storage

Argon charged,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Terlipressin acetate is a Vasotocin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective Vasotocin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research

In Vitro

Terlipressin (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells. Terlipressin inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: IEC-6 cells induced by oxygen and glucose deprivation/re-oxygenation (OGD/R) Concentration: 25 nM Incubation Time: 24 hours, 48 hours, 72 hours Result: Significantly increased the proliferation of IEC-6 cells.

In Vivo

Using a mouse nonlethal hepatic ischemia-reperfusion (IR) model, Terlipressin administration significantly ameliorates IR-induced liver apoptosis, necrosis and inflammation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Vasotocin V1 receptor

Specifications

Synonyms

Q27251135 | 14636-12-5 , Terlipressin | GLXC-25927 | HY-12554A | Heamopressin | UNII-10B4G9161D | Terlipressin (acetate) | Terlipressin diacetate anhydrous | Terlipressin acetate anhydrous | 10B4G9161D | Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-Nh2

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Terlipressin acetate is a Vasotocin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective Vasotocin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. T

Storage

Argon charged, Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC(=O)O.CC(=O)O.C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CCCCN)C(=O)NCC(=O)N
• IUPAC Name: acetic acid;(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide
• InChIKey: WNFVFDPQEHRNTC-LWCZBKQBSA-N
• INCHI: 1S/C52H74N16O15S2.2C2H4O2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37;2*1-2(3)4/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80);2*1H3,(H,3,4)/t31-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1
• Isomeric SMILES: CC(=O)O.CC(=O)O.C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N
• Alternate CAS: 1884420-36-3,914453-96-6
• PubChem CID: 72941948
• Molecular Weight: 1347.48

Chemical and Physical Properties

• Solubility: H2O : 100 mg/mL (74.21 mM; Need ultrasonic) DMSO : 50 mg/mL (37.11 mM; Need ultrasonic)