Fmoc-Ala-OH - ≥98% , CAS No.35661-39-3

CAS: 35661-39-3 Cat. No.: F105469 Molecular Weight: 311.33 Beilstein Registry Number: 2225975 EC Number: 252-660-6

GRADE & PURITY ≥98%

Synonyms

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid | isopentan-1-ol | Fmoc-L-Alanine monohydrate | SCHEMBL119044 | L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- | N-alpha-FMOC-L-ALANINE | STL466185 | M03347 | FMOC-L-alpha-Alanine | Parald

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Fmoc-Ala-OH also known as Fmoc-L-alanine, is a versatile reagent used in Fmoc solid-phase peptide synthesis.

Specifications

Synonyms

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid | isopentan-1-ol | Fmoc-L-Alanine monohydrate | SCHEMBL119044 | L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- | N-alpha-FMOC-L-ALANINE | STL466185 | M03347 | FMOC-L-alpha-Alanine | Parald

Specifications & Purity

≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504764092
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764092
• Canonical Smiles: CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
• InChIKey: QWXZOFZKSQXPDC-NSHDSACASA-N
• INCHI: 1S/C18H17NO4/c1-11(17(20)21)19-18(22)23-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16H,10H2,1H3,(H,19,22)(H,20,21)/t11-/m0/s1
• Isomeric SMILES: C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
• WGK Germany: 3
• Alternate CAS: 207291-76-7
• Molecular Weight: 311.33
• Beilstein: 2225975
• Reaxy-Rn: 2339665
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339665&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Alanine and derivatives Carbamate esters Monocarboxylic acids and derivatives Carboxylic acids Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Alanine or derivatives - Alpha-amino acid or derivatives - Carbamic acid ester - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water.
• Specific Rotation[α]: -18.5 ° (C=1, DMF)
• Melt Point(°C): 150-157°C
• Molecular Weight: 311.300 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 311.116 Da
• Monoisotopic Mass: 311.116 Da
• Topological Polar Surface Area: 75.600 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 430.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Hui Li, Fei Li, Fang Liu, Xiao Chen, Wenyuan Xu, Liang Shen, Jingkun Xu, Rui Yang, Ge Zhang.  (2022)  High-Quality Conjugated Polymers Achieving Ultra-Trace Detection of Cr2O72− in Agricultural Products.  MOLECULES,  27  (13): (4294).  [PMID:35807539] [10.3390/molecules27134294]

2. Jiao Li, Yuanyuan Li, Tong Chen, Luan Xu, Xiaoyan Liu, Xiaoli Zhang, Haixia Zhang.  (2013)  Preparation, chromatographic evaluation and comparison between linear peptide- and cyclopeptide-bonded stationary phases.  TALANTA,      [PMID:23618153] [10.1016/j.talanta.2013.02.005]

3. Wei Cheng, Haijing Qu, Jiaojiao Yang, Han Chen, Yuqing Pan, Zhiran Duan, Xiangdong Xue.  (2025)  Hierarchically Engineered Self-Adaptive Nanoplatform Guided Intuitive and Precision Interventions for Deep-Seated Glioblastoma.  ACS Nano,      [PMID:39754309] [10.1021/acsnano.4c11006]

4. Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue.  (2025)  Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma.  ACS Nano,      [PMID:40698543] [10.1021/acsnano.5c08928]