Fmoc-Trp(Boc)-OH - ≥97% , CAS No.143824-78-6

CAS: 143824-78-6 Cat. No.: F116800 Molecular Weight: 526.58 Beilstein Registry Number: 7698009 EC Number: 604-383-0

GRADE & PURITY ≥97%

Synonyms

MFCD00038176 | EN300-249916 | N- | Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(tert-butoxycarbonyl)-L-tryptophan | F0507 | N1-Boc-Nalpha-Fmoc-L-tryptophan | N-tert-Butoxycarbonyl-N-9-fluorenylmethoxycarbonyl-L-tryptophan | (2S)-3-{1-[(tert-butoxy)carbonyl]

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of Glukagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes[1] and various peptides by Fmoc solid phase peptide synthesis (SPPS).

Specifications

Synonyms

MFCD00038176 | EN300-249916 | N- | Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(tert-butoxycarbonyl)-L-tryptophan | F0507 | N1-Boc-Nalpha-Fmoc-L-tryptophan | N-tert-Butoxycarbonyl-N-9-fluorenylmethoxycarbonyl-L-tryptophan | (2S)-3-{1-[(tert-butoxy)carbonyl]

Specifications & Purity

≥97%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 504764970
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764970
• Canonical Smiles: CC(C)(C)OC(=O)N1C=C(C2=CC=CC=C21)CC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]propanoic acid
• InChIKey: ADOHASQZJSJZBT-SANMLTNESA-N
• INCHI: 1S/C31H30N2O6/c1-31(2,3)39-30(37)33-17-19(20-10-8-9-15-27(20)33)16-26(28(34)35)32-29(36)38-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1
• Isomeric SMILES: CC(C)(C)OC(=O)N1C=C(C2=CC=CC=C21)C[C@@H](C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
• WGK Germany: 3
• Molecular Weight: 526.58
• Beilstein: 7698009
• Reaxy-Rn: 13169226
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13169226&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Indolecarboxylic acids 3-alkylindoles Alpha amino acids and derivatives Pyrrole carboxylic acids and derivatives Substituted pyrroles Carbamate esters Heteroaromatic compounds Organic carbonic acids and derivatives Azacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Fluorene - Indolecarboxylic acid - Indolecarboxylic acid derivative - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - Pyrrole-1-carboxylic acid or derivatives - Substituted pyrrole - Heteroaromatic compound - Carbamic acid ester - Pyrrole - Carbonic acid derivative - Carboxylic acid derivative - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Specific Rotation[α]: -20 ° (C=1, DMF)
• Melt Point(°C): 99 °C
• Molecular Weight: 526.600 g/mol
• XLogP3: 6.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 526.21 Da
• Monoisotopic Mass: 526.21 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 880.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1