Genistin - ≥95%(HPLC), from Glycine max (soybean) , CAS No.529-59-9

CAS: 529-59-9 Cat. No.: G113838 Molecular Weight: 432.38 Beilstein Registry Number: 64479 EC Number: 610-921-5
AVAILABLE TO ORDER
GRADE & PURITY ≥95%(HPLC) from Glycine max (soybean)
Synonyms
CHEBI:27514 | AKOS025146960 | MFCD00016883 | NSC 5112 | AS-11684 | G0358 | Genistin, analytical standard | Genistein 7-O-b-D-glucopyranoside | Genistein glucoside | 5,4'-DI-HYDROXYISOFLAVONE-7-O-.BETA.-D-GLUCOPYRANOSIDE | 5-hydroxy-3-(4-hydroxyphenyl)-4-o
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25mg
G113838-25mg
3
$9.90
250mg
G113838-250mg
3
$37.90
1g
G113838-1g
1
$119.90
5g
G113838-5g
3
$449.90
25g
G113838-25g
1
$1,799.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥95%(HPLC), from Glycine max (soybean) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 27 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Selective inhibitor of mammalian terminal deoxynucleotidyl transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases

Specifications

Synonyms
CHEBI:27514 | AKOS025146960 | MFCD00016883 | NSC 5112 | AS-11684 | G0358 | Genistin, analytical standard | Genistein 7-O-b-D-glucopyranoside | Genistein glucoside | 5, 4'-DI-HYDROXYISOFLAVONE-7-O-.BETA.-D-GLUCOPYRANOSIDE | 5-hydroxy-3-(4-hydroxyphenyl)-4-o
Specifications & Purity
≥95%(HPLC), from Glycine max (soybean)
Biochemical and Physiological Mechanisms
Inactive analog of genistein; useful as a negative control for genistein and other tyrosine kinase inhibitors.Isoflavone glycoside. Inactive analog of Genistein. Glycoside of Genistein. Selective terminal deoxyribonucleotidyltransferase inhibitor. Stimula
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥95%(HPLC)
Names and Identifiers
Pubchem Sid504763352
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504763352
Canonical SmilesC1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)OC4C(C(C(C(O4)CO)O)O)O)O
IUPAC Name5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
InChIKeyZCOLJUOHXJRHDI-CMWLGVBASA-N
INCHI1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
Isomeric SMILES C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
WGK Germany 3
RTECS DJ3093000
Molecular Weight 432.38
Beilstein 64479
Reaxy-Rn 24724148
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24724148&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClassIsoflavonoids
SubclassIsoflavonoid O-glycosides
Intermediate Tree Nodes Not available
Direct ParentIsoflavonoid O-glycosides
Alternative Parents Hydroxyisoflavonoids  Isoflavones  Phenolic glycosides  Hexoses  Chromones  O-glycosyl compounds  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Pyranones and derivatives  Benzene and substituted derivatives  Oxanes  Vinylogous acids  Heteroaromatic compounds  Secondary alcohols  Oxacyclic compounds  Polyols  Acetals  Primary alcohols  Hydrocarbon derivatives  Organic oxides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Isoflavonoid-7-o-glycoside - Isoflavonoid o-glycoside - Isoflavone - Hydroxyisoflavonoid - Phenolic glycoside - Hexose monosaccharide - O-glycosyl compound - Glycosyl compound - Chromone - Benzopyran - 1-benzopyran - Pyranone - 1-hydroxy-2-unsubstituted benzenoid - Phenol - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Pyran - Monocyclic benzene moiety - Oxane - Monosaccharide - Vinylogous acid - Heteroaromatic compound - Secondary alcohol - Acetal - Oxacycle - Organoheterocyclic compound - Polyol - Alcohol - Hydrocarbon derivative - Organic oxide - Primary alcohol - Organic oxygen compound - Organooxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as isoflavonoid o-glycosides. These are o-glycosylated derivatives of isoflavonoids, which are natural products derived from 3-phenylchromen-4-one.
External Descriptors isoflavones - Isoflavonoids
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ishikawa (877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dsDNA (365 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
quadruplex DNA (2700 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LLC-PK1 (2135 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spodoptera litura (1708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
I1825180Certificate of AnalysisApr 15, 2026 G113838
I1825179Certificate of AnalysisApr 15, 2026 G113838
F2201258Certificate of AnalysisMar 16, 2026 G113838
E1803103Certificate of AnalysisJan 05, 2026 G113838
E1803102Certificate of AnalysisJan 05, 2026 G113838
J2527164Certificate of AnalysisNov 08, 2025 G113838
A1823043Certificate of AnalysisAug 18, 2025 G113838
A1823040Certificate of AnalysisAug 18, 2025 G113838
Chemical and Physical Properties
SensitivityHygroscopic,Heat Sensitive
Melt Point(°C)265°C
Molecular Weight432.400 g/mol
XLogP30.900
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass432.106 Da
Monoisotopic Mass432.106 Da
Topological Polar Surface Area166.000 Ų
Heavy Atom Count31
Formal Charge0
Complexity675.000
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo.  (2022)  Chemical composition and anti-inflammatory activities of Castanopsis honey.  Food & Function,  14  (1): (250-261).  [PMID:36484340] [10.1039/D2FO02233H]
2. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372] [10.1039/D1FO03816H]
3. Lei Du, Kum-Song Ro, Yiji Zhang, Ya-Jie Tang, Wanbang Li, Jingli Xie, Dongzhi Wei.  (2021)  Effects of lactiplantibacillus plantarum X7021 on physicochemical properties, purines, isoflavones and volatile compounds of fermented soymilk.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2021.12.028]
4. Wang Huawei, Shan Xiajing, Ren Mengtian, Shang Mengdi, Zhou Chuanzheng.  (2021)  Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis.  NUCLEIC ACIDS RESEARCH,  49  (21): (12306-12319).  [PMID:34865123] [10.1093/nar/gkab1121]
5. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang.  (2020)  The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract.  Foods,  (12): (1816).  [PMID:33297502] [10.3390/foods9121816]
6. Xiaoyi Qu, Bo Ding, Jing Li, Meng Liang, Liqin Du, Yutuo Wei, Ribo Huang, Hao Pang.  (2020)  Characterization of a GH3 halophilic β-glucosidase from Pseudoalteromonas and its NaCl-induced activity toward isoflavones.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:32763400] [10.1016/j.ijbiomac.2020.07.300]
7. Yu-ting Li, Ming-shun Chen, Li-zhen Deng, Ya-zhen Liang, Yi-kun Liu, Wei Liu, Jun Chen, Cheng-mei Liu.  (2020)  Whole soybean milk produced by a novel industry-scale micofluidizer system without soaking and filtering.  JOURNAL OF FOOD ENGINEERING,      [PMID:] [10.1016/j.jfoodeng.2020.110228]
8. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song.  (2020)  Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:32480277] [10.1016/j.saa.2020.118519]
9. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang.  (2020)  Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations.  FOOD CHEMISTRY,      [PMID:32330646] [10.1016/j.foodchem.2020.126807]
10. Xianli Gao, Ermeng Liu, Junke Zhang, Mingquan Yang, Sui Chen, Zhan Liu, Haile Ma, Feng Hu.  (2019)  Effects of sonication during moromi fermentation on antioxidant activities of compounds in raw soy sauce.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.108605]
11. Xiaonan Zhang, Hongwei Zhang, Xinghao Xia, Nan Pu, Zhuping Yu, Mourtada Nabih, Ying Zhu, Shuang Zhang, Lianzhou Jiang.  (2019)  Preparation and physicochemical characterization of soy isoflavone (SIF) nanoparticles by a liquid antisolvent precipitation method.  ADVANCED POWDER TECHNOLOGY,      [PMID:] [10.1016/j.apt.2019.04.030]
12. Xingyu Hou, Wei Huang, Fugui Zhu, Fang Geng, Miaomiao Tian.  (2018)  A new boronate-affinity hollow solid phase extraction adsorbent for the enrichment of cis-diol-containing isoflavones in soybean milk samples.  Analytical Methods,  11  (3): (317-326).  [PMID:] [10.1039/C8AY02311E]
13. Hu Yue, Xia Qinfei, Huang Wei, Hou Xingyu, Tian Miaomiao.  (2017)  Boronate-modified hollow molecularly imprinted polymers for selective enrichment of glycosides.  MICROCHIMICA ACTA,  185  (1): (1-9).  [PMID:29594569] [10.1007/s00604-017-2608-2]
14. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang.  (2017)  Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr).  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2017.03.003]
15. Yonggang Feng, Qin Liu, Lifang Ye, Quanzhou Wu, Jianfeng He.  (2016)  Ordered macroporous quercetin molecularly imprinted polymers: Preparation, characterization, and separation performance.  JOURNAL OF SEPARATION SCIENCE,  40  (4): (971-978).  [PMID:28012243] [10.1002/jssc.201601011]
16. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan.  (2016)  The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum.  FOOD CHEMISTRY,      [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
17. Liyang Wei, Qian Hu, Lei He, Guoping Li, Jiukai Zhang, Ying Chen.  (2024)  Diversity in storage age enables discrepancy in quality attributes and metabolic profile of Citrus grandis “Tomentosa” in China.  JOURNAL OF FOOD SCIENCE,      [PMID:38258880] [10.1111/1750-3841.16935]
18. Si-Yi Mo, Yuan Li, Ying-Ying Fan, Yao-Jun Zhang, Jing-Wen Liu, Xu-Tong Song, Xiao-Xiang Xu, Ye Cao, Jian-Qiu Jin, Qiu-Fei Xie.  (2025)  Genistein reverses the exacerbating effect of 17β-estradiol on experimental occlusal interference induced chronic masseter hyperalgesia through suppressing ERK1/2 signal pathway in spinal trigeminal nucleus of ovariectomized rats.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40139418] [10.1016/j.ejphar.2025.177544]
19. Qifang Sun, Furu Wu, Wei Wu, Wenjie Yu, Gaowei Zhang, Xueyong Huang, Yingbin Hao, Liping Luo.  (2024)  Identification and quality evaluation of Lushan Yunwu tea from different geographical origins based on metabolomics.  FOOD RESEARCH INTERNATIONAL,      [PMID:38729702] [10.1016/j.foodres.2024.114379]
20. Xia Yang, Yun Wang, Yan Sun, Jiali Guo, Zhaojun Geng, Bingyao Wei, Peiqin Li, Guanghui Tang.  (2025)  Integrated transcriptomics and metabolomics revealed the role of the flavonoid pathway in the resistance of Zanthoxylum bungeanum against leaf rust.  SCIENTIA HORTICULTURAE,      [PMID:] [10.1016/j.scienta.2025.113990]
21. Shangguang Du, Hao Wan, Jun Luo, Xiaohua Duan, Zhengrong Zou.  (2024)  Metabolic profiling of Citrus maxima L. seedlings in response to cadmium stress using UPLC-QTOF-MS.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:38996714] [10.1016/j.plaphy.2024.108920]
22. Mian Wang, Yiting Wang, Muhammad Bilal, Chong Xie, Pei Wang, Xin Rui, Runqiang Yang.  (2024)  UV-B Radiation Exhibited Tissue-Specific Regulation of Isoflavone Biosynthesis in Soybean Cell Suspension Cultures.  Foods,  13  (15): (2385).  [PMID:39123575] [10.3390/foods13152385]
23. Jiayu Zhang, Xiujie Jiang, Qingpeng Xu, Weidong Li, Dongjie Zhang.  (2025)  Lipidomic Analysis Reveals the Anti-Obesity and Hepatoprotective Effects of Flavonoid Mimetic Components in Adzuki Beans on High-Fat Diet-Induced Obese Mice.  Foods,  14  (18): (3191).  [PMID:41008164] [10.3390/foods14183191]
24. Hui Cao, Xiaojuan Liu, Nataša Poklar Ulrih, Pradeep K. Sengupta, Jianbo Xiao.  (2018)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.  FOOD CHEMISTRY,      [PMID:30174044] [10.1016/j.foodchem.2018.07.111]
25. Haolin Zhang, Jingjing Zhang, Hui Cao, Petra Högger, Randolph Arroo, Mohamed A. Farag, Avi Shpigelman, Jianbo Xiao, Chunlin Li.  (2025)  Amination of Flavonoids Possessing a Pyrogallol Group in Cell Culture Medium at 37°C.  Food Frontiers,  (2): (1058-1078).  [PMID:] [10.1002/fft2.70002]
26. Yang Lu, Lianghua Xie, Jiahong Xie, Gexin Liu, Jiaqi Fu, Luheng Zou, Qiu Lin, Yong Wang, Wei Chen.  (2025)  Comprehensive engineering of novel glycosyltransferase for efficient, donor-promiscuous, and regioselective glycosylation of flavonoids.  Science Advances,  11  (40):   [PMID:41042874] [10.1126/sciadv.adu5064]
27. Wang Yue, Tang Xiaohan, Zhao Huarong, Pan Yue, Zhang Dingnan, Liu He, Zhu Danshi.  (2026)  Effects of monascus -fermented soybean powder on the quality, isoflavones composition and sensory acceptance of steamed bread.  JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,      [PMID:] [10.1007/s13197-026-06557-3]
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