Ginkgolide A from Ginkgo biloba leaves - Moligand™, analytical standard, ≥98% , Antagonist of PAF receptor, CAS No.15291-75-5, Antagonist of PAF receptor
Ginkgolide A from Ginkgo biloba leaves - Moligand™, analytical standard, ≥98% , Antagonist of PAF receptor, CAS No.15291-75-5, Antagonist of PAF receptor
GRADE & PURITYAnalytical standard?Analytical standard — certified-purity material for quantitative calibration. Use to prepare calibration standards and validate analytical methods.Moligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Highly active platelet -activating factor (PAF) antagonist. Biologically active terpinoid. Anti-inflammatory effects in vivo.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Analytical standard, Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of PAF receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as ginkgolides and bilobalides. These are diterpene lactones with a structure based either on the gingkolide or the bilobalide skeleton. The ginkgolide skeleton is a very rigid structure consisting of hexacyclic C20 trilactone. The cis-fused F/A/D/C ring junction forms an empty semi-ball hole, the D ring contains a cage form tetrahydrofuran ring which occupies the center of the empty hole, and the oxygen atoms of the D,C and F ring and 10-hydroxyl group consist of an analogous crown ether structure.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Meng Wang, Xiangling Sun, Ying Wang, Xuan Deng, Jianing Miao, Donghe Zhao, Kunqi Sun, Minrui Li, Xiaoyi Wang, Wenlong Sun, Jie Qin. (2022) Construction of Selenium Nanoparticle-Loaded Mesoporous Silica Nanoparticles with Potential Antioxidant and Antitumor Activities as a Selenium Supplement. ACS Omega, [PMID:36530304][10.1021/acsomega.2c04975]
2.Lingling Wang, Xiuhua Zhao, Fengjian Yang, Weiwei Wu, Yanjie Liu, Li Wang, Lu Wang, Zijian Wang. (2019) Enhanced bioaccessibility in vitro and bioavailability of Ginkgo biloba extract nanoparticles prepared by liquid anti-solvent precipitation. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 54 (6):(2266-2276). [PMID:][10.1111/ijfs.14141]
3.Lingling Wang, Xiuhua Zhao, Yuangang Zu, Weiwei Wu, Yuanyuan Li, Chang Zu, Yin Zhang. (2016) Enhanced dissolution rate and oral bioavailability of ginkgo biloba extract by preparing nanoparticles via emulsion solvent evaporation combined with freeze drying (ESE-FR). RSC Advances, 6 (81):(77346-77357). [PMID:][10.1039/C6RA14771B]
4.Yuan Gang Zu, Lingling Wang, Xiuhua Zhao, Yuanyuan Li, Weiwei Wu, Chang Zu, Yannian Huang, Mingfang Wu, Ziqi Feng. (2016) Purification of Ginkgo biloba Extract by Antisolvent Recrystallization. CHEMICAL ENGINEERING & TECHNOLOGY, 39 (7):(1301-1308). [PMID:][10.1002/ceat.201500691]
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