Glycolide - ≥98% , CAS No.502-97-6

CAS: 502-97-6 Cat. No.: G156824 Molecular Weight: 116.07 EC Number: 207-954-9

GRADE & PURITY ≥98%

Synonyms

Acetic acid, bimol. cyclic ester | SCHEMBL15066 | 1,4-Dioxane-2,5-dione | AS-57477 | DTXSID8060115 | Glycolide | UNII-YRZ676PGU6 | Glycollide | EINECS 207-954-9 | FT-0606899 | 2,5-dioxo-1,4-dioxane

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.

Application：

Glycolide can be used as a monomer in the preparation of poly(lactic-co-glycolide)(PGLA) via copolymerization with lactide monomer. PGLA is further used in the following applications:
Porous PGLA microsphere scaffolds are used in bone repair applications.
Encapsulated PGLA nanoparticles can be used in drug delivery and tissue engineering applications. Polymeric micro/nanoparticles made from PLGA have gained significant interest for their appealing characteristics, including biodegradability, biocompatibility, prolonged drug release, and safeguarding the drug against degradation.
It can also be used to synthesize poly(glycolide-caprolactone)(PGCL) copolymers applicable as bioabsorbable suture materials.

Specifications

Synonyms

Acetic acid, bimol. cyclic ester | SCHEMBL15066 | 1, 4-Dioxane-2, 5-dione | AS-57477 | DTXSID8060115 | Glycolide | UNII-YRZ676PGU6 | Glycollide | EINECS 207-954-9 | FT-0606899 | 2, 5-dioxo-1, 4-dioxane

Specifications & Purity

≥98%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488183682
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488183682
• Canonical Smiles: C1C(=O)OCC(=O)O1
• IUPAC Name: 1,4-dioxane-2,5-dione
• InChIKey: RKDVKSZUMVYZHH-UHFFFAOYSA-N
• INCHI: 1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
• Isomeric SMILES: C1C(=O)OCC(=O)O1
• Molecular Weight: 116.07
• Reaxy-Rn: 112109
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=112109&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Dioxanes
      • Subclass 1,4-dioxanes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Dioxanes
• Subclass: 1,4-dioxanes
• Intermediate Tree Nodes: Not available
• Direct Parent: 1,4-dioxanes
• Alternative Parents: Dicarboxylic acids and derivatives Lactones Carboxylic acid esters Oxacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Dicarboxylic acid or derivatives - Para-dioxane - Lactone - Carboxylic acid ester - Oxacycle - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as 1,4-dioxanes. These are organic compounds containing 1,4-dioxane, an aliphatic six-member ring with two oxygen atoms in ring positions 1 and 4.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in Dimethylformamide
• Sensitivity: Moisture & air & heat sensitive
• Boil Point(°C): 130℃
• Melt Point(°C): 82-86℃
• Molecular Weight: 116.070 g/mol
• XLogP3: -0.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 116.011 Da
• Monoisotopic Mass: 116.011 Da
• Topological Polar Surface Area: 52.600 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 112.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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