Guanosine 5′-monophosphate disodium salt hydrate - ≥98% , CAS No.5550-12-9

CAS: 5550-12-9 Cat. No.: G112861 Molecular Weight: 407.18 EC Number: 226-914-1

GRADE & PURITY ≥98%

Synonyms

Sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate | DISODIUM 5'-GUANYLATE | disodium 5'--guanylate | Guanosine-5'-monophosphate disodium salt | Q905776 | AKOS015896908 | J-700176 | Disodium guanos

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

Guanosine 5′-monophosphate is suitable for use in:

· the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure

· the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes

· the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS

Specifications

Synonyms

Sodium ((2R, 3S, 4R, 5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3, 4-dihydroxytetrahydrofuran-2-yl)methyl phosphate | DISODIUM 5'-GUANYLATE | disodium 5'--guanylate | Guanosine-5'-monophosphate disodium salt | Q905776 | AKOS015896908 | J-700176 | Disodium guanos

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutam

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504773288
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773288
• Canonical Smiles: C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+]
• IUPAC Name: disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
• InChIKey: PVBRXXAAPNGWGE-LGVAUZIVSA-L
• INCHI: 1S/C10H14N5O8P.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
• Isomeric SMILES: C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+]
• RTECS: MF9290000
• Alternate CAS: 85-32-5
• Molecular Weight: 407.18
• Reaxy-Rn: 30714500
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30714500&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Purine nucleotides
      • Subclass Purine ribonucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Purine nucleotides
• Subclass: Purine ribonucleotides
• Intermediate Tree Nodes: Not available
• Direct Parent: Purine ribonucleoside monophosphates
• Alternative Parents: Pentose phosphates Glycosylamines 6-oxopurines Hypoxanthines Monosaccharide phosphates Pyrimidones Aminopyrimidines and derivatives Alkyl phosphates N-substituted imidazoles Tetrahydrofurans Vinylogous amides Heteroaromatic compounds Secondary alcohols 1,2-diols Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic zwitterions Primary amines Organopnictogen compounds Organic sodium salts Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purine ribonucleoside monophosphate - Pentose phosphate - Pentose-5-phosphate - Glycosyl compound - N-glycosyl compound - 6-oxopurine - Pentose monosaccharide - Hypoxanthine - Monosaccharide phosphate - Purine - Imidazopyrimidine - Pyrimidone - Aminopyrimidine - Monosaccharide - N-substituted imidazole - Alkyl phosphate - Pyrimidine - Organic phosphoric acid derivative - Phosphoric acid ester - Vinylogous amide - Tetrahydrofuran - Heteroaromatic compound - Azole - Imidazole - Secondary alcohol - 1,2-diol - Oxacycle - Azacycle - Organic alkali metal salt - Organoheterocyclic compound - Organic salt - Amine - Organic sodium salt - Alcohol - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic zwitterion - Primary amine - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: H2O: soluble 50 mg/mL, clear, colorless to faintly yellow
• Sensitivity: Moisture sensitive
• Melt Point(°C): 300°C
• Molecular Weight: 407.180 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 3
• Exact Mass: 407.022 Da
• Monoisotopic Mass: 407.022 Da
• Topological Polar Surface Area: 207.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 586.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

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